Peptide-based cancer therapy: Opportunity and challenge

被引：265
|
作者：
Wu, Dongdong [1 ]
Gao, Yanfeng [2 ]
Qi, Yuanming [2 ]
Chen, Lixiang [2 ]
Ma, Yuanfang [1 ]
Li, Yanzhang [1 ]
机构：
[1] Henan Univ, Coll Med, Kaifeng 475004, Henan, Peoples R China
[2] Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Henan, Peoples R China
来源：
CANCER LETTERS | 2014年 / 351卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Cancer therapy; Peptide; Anticancer mechanism; Modification strategy; ENDOTHELIAL GROWTH-FACTOR; PHAGE DISPLAY LIBRARY; HUMAN FIBROSARCOMA CELLS; EXHIBITS ANTITUMOR-ACTIVITY; TARGETED DRUG-DELIVERY; INHIBITS TUMOR-GROWTH; ANTIMICROBIAL PEPTIDE; BREAST-CANCER; ANTICANCER ACTIVITY; IN-VITRO;
D O I：
10.1016/j.canlet.2014.05.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer is one of the leading causes of death worldwide. Conventional cancer therapies mainly focus on mass cell killing without high specificity and often cause severe side effects and toxicities. Peptides are a novel class of anticancer agents that could specifically target cancer cells with lower toxicity to normal tissues, which will offer new opportunities for cancer prevention and treatment. Anticancer peptides face several therapeutic challenges. In this review, we present the sources and mechanisms of anticancer peptides and further discuss modification strategies to improve the anticancer effects of bioactive peptides. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：13 / 22
页数：10
相关论文
共 50 条
  • [31] Peptide-based vaccination for colorectal cancer
    Tsuruma, T
    Hata, F
    Furuhata, T
    Ohmura, T
    Katsuramaki, T
    Yamaguchi, K
    Kimura, Y
    Torigoe, T
    Sato, N
    Hirata, K
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2005, 5 (06) : 799 - 807
  • [32] Versatile Peptide-Based Nanosystems for Photodynamic Therapy
    Li, Qiuyan
    Ming, Ruiqi
    Huang, Lili
    Zhang, Ruoyu
    PHARMACEUTICS, 2024, 16 (02)
  • [33] Functional peptide-based nanoparticles for photodynamic therapy
    Han, Kai
    Ma, Zhaoyu
    Han, Heyou
    JOURNAL OF MATERIALS CHEMISTRY B, 2018, 6 (01) : 25 - 38
  • [34] Recent advances in antimicrobial peptide-based therapy
    Mulukutla, Aditya
    Shreshtha, Romi
    Deb, Vishal Kumar
    Chatterjee, Pallabi
    Jain, Utkarsh
    Chauhan, Nidhi
    BIOORGANIC CHEMISTRY, 2024, 145
  • [35] Peptide-based therapy in lupus: Promising data
    Mormeaux, Fanny
    Muller, Sylviane
    IMMUNE-MEDIATED DISEASES: FROM THEORY TO THERAPY, 2007, 601 : 105 - 112
  • [36] Peptide-based Radiopharmaceuticals for Targeted Tumor Therapy
    Dong, C.
    Liu, Z.
    Wang, F.
    CURRENT MEDICINAL CHEMISTRY, 2014, 21 (01) : 139 - 152
  • [37] Peptide-Based Vaccination Therapy for Rheumatic Diseases
    Wang, Bin
    Chen, Shiju
    Zheng, Qing
    Liu, Yuan
    Shi, Guixiu
    JOURNAL OF IMMUNOLOGY RESEARCH, 2020, 2020
  • [38] Peptide-based immunoassays for biomarkers detection: A challenge for translational research
    Papini, Anna Maria
    JOURNAL OF PEPTIDE SCIENCE, 2008, 14 (08) : 8 - 8
  • [39] Present status and future perspective of peptide-based vaccine therapy for urological cancer
    Obara, Wataru
    Kanehira, Mitsugu
    Katagiri, Toyomasa
    Kato, Renpei
    Kato, Yoichiro
    Takata, Ryo
    CANCER SCIENCE, 2018, 109 (03): : 550 - 559
  • [40] Engineering personalized peptide-based cancer nanovaccines
    Kakwere, Hamilton
    Zhang, Hua
    Kheirolomoom, Azadeh
    Ferrara, Katherine
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 258
12345