Therapeutic use of a clinical stage CCR2 inhibitor, CCX872, in obesity-associated steatohepatitis

被引：0

作者：

Parker, Richard ^{[1
,2
]}

Walters, Matthew ^{[2
]}

Ertl, Linda ^{[2
]}

Ebsworth, Karen ^{[2
]}

Tan, Joanne ^{[2
]}

McMahon, Jeff ^{[2
]}

Powers, Jay ^{[2
]}

Adams, David ^{[1
]}

Jaen, Juan ^{[2
]}

Schall, Tom ^{[2
]}

机构：

[1] Univ Birmingham, Liver Res Ctr, Birmingham B15 2TT, W Midlands, England

[2] ChemoCentryx Inc, Mountain View, CA USA

来源：

LANCET | 2014年 / 383卷

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：78 / 78

页数：1

共 10 条

[1] THERAPEUTIC USE OF A CLINICAL STAGE CCR2 INHIBITOR, CCX872, IMPROVES OBESITY ASSOCIATED STEATOHEPATITIS IN MICE
Parker, R.
Walters, M. J.
Ertle, L.
Ebsworth, K.
Tan, J.
Sietz, L.
McMahon, J.
Dairaghi, D.
Powers, J.
Adams, D.
Jaen, J.
Schall, T.
JOURNAL OF HEPATOLOGY, 2014, 60 (01) : S149 - S149
[2] Reduction of Liver Fibrosis by CCR2 antagonist CCX872 in Murine Models of NASH
Miao, Zhenhua
Newland, Dale
Ertl, Linda
Parker, Richard
McMahon, Jeff
Zhang, Penglie
Adams, David H.
Scholl, Thomas J.
Charo, Israel
HEPATOLOGY, 2016, 64 : 763A - 763A
[3] Reduction of Liver Fibrosis by CCR2 Antagonist CCX872 in Murine Models of NASH
Miao, Zhenhua
Newland, Dale
Ertl, Linda
Parker, Richard
McMahon, Jeff
Zhang, Penglie
Adams, David
Schall, Thomas
Charo, Israel
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2016, 111 : S398 - S398
[4] CLINICAL DEVELOPMENT OF CCR2 ANTAGONISTS CCX140-B AND CCX872-B
Bekker, Pirow
Charvat, Trevor
Miao, Shichang
Dairaghi, Dan
Lohr, Lisa
Sullivan, Timothy
Seitz, Lisa
Miao, Zhenhua
Powers, Jay
Jaen, Juan
Schall, Thomas
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2013, 28 : 17 - 17
[5] Phase 1 Clinical Evaluation of the CCR2 Antagonist CCX872-B
Bekker, Pirow
Charvat, Trevor
Miao, Shichang
Lohr, Lisa
Sullivan, Timothy
Miao, Zhenhua
Powers, Jay
Jaen, Juan
Schall, Thomas J.
DIABETES, 2013, 62 : A292 - A293
[6] Orally administered CCR2 selective inhibitor CCX872-b clinical trial in pancreatic cancer.
Noel, Marcus Smith
Hezel, Aram F.
Linehan, David
Wang-Gillam, Andrea
Eskens, Ferry
Sleijfer, Stefan
Desar, Ingrid
Erdkamp, Frans
Wilmink, Johanna
Diehl, Janet
Potarca, Antonia
Zhao, Niky
Deng, Jun
Lohr, Lisa
Miao, Shichang
Charo, Israel
Singh, Rajinder
Schall, Thomas J.
Bekker, Pirow
JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (04)
[7] Overall survival in a trial of orally administered CCR2 inhibitor CCX872 in locally advanced/metastatic pancreatic cancer: Correlation with blood monocyte counts.
Linehan, David
Noel, Marcus Smith
Hezel, Aram F.
Wang-Gillam, Andrea
Eskens, Ferry
Sleijfer, Stefan
Desar, Ingrid M. E.
Erdkamp, Frans
Wilmink, Johanna
Diehl, Janet
Potarca, Antonia
Zhao, Niky
Miao, Shichang
Deng, Jun
Hillson, Jan
Bekker, Pirow
Schall, Thomas J.
Singh, Rajinder
JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (05)
[8] CCX872: Pharmacodynamic study of a potent and selective CCR2 antagonist in human volunteers and plans for phase Ib trial in patients with pancreatic cancer
Duliege, Anne-Marie
Sleijfer, Stefan
Bischof, Ashley
Tan, Joanne
Zhang, Penglie
Seitz, Lisa
Dairaghi, Daniel
Bekker, Pirow
Charo, Israel
Schall, Thomas
CANCER RESEARCH, 2015, 75
[9] The inhibition of CCR2 to modify the microenvironment in pancreatic cancer mouse model and to support the profiling of the CCR2 inhibitor CCX872-B in patients.
Wang-Gillam, Andrea
Noel, Marcus Smith
Sleijfer, Stefan
Jung, Heiyoun
Lohr, Lisa
Zhao, Niky
Miao, Shichang
Potarca, Antonia
Charo, Israel
Bekker, Petrus
Schall, Thomas J.
JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
[10] CCR2 INHIBITOR CCX140 EFFECTIVE IN PHASE 2 CLINICAL TRIAL IN DIABETIC NEPHROPATHY
de Zeeuw, Dick
Henkel, Elena
Psottova, Jana
Paragh, Gyorgy
Mehling, Heidrun
Hasslacher, Christopher
Potarca, Antonia
Bekker, Pirow
Schall, Thomas J.
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2015, 30

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