Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.

被引：6

作者：

Legrave, Nathalie ^{[1
]}

Hamrouni-Buonomo, Souhir ^{[1
,2
]}

Dufies, Maeva ^{[3
]}

Guerineau, Vincent ^{[4
]}

Vacelet, Jean ^{[5
]}

Auberger, Patrick ^{[3
]}

Amade, Philippe ^{[1
]}

Mehiri, Mohamed ^{[1
]}

机构：

[1] Univ Nice Sophia Antipolis, Chem Inst Nice ICN, CNRS, UMR 7272, F-06108 Nice 02, France

[2] Carthage Univ, Agron Natl Inst Tunisia INAT, UR Ecosyst & Aquat Ressources UR03AGRO1, Tunis 1082, Tunisia

[3] INSERM, Mediterranean Ctr Mol Med C3M, Team Cell Death Differentiat & Canc 2, UMR 1065, F-06204 Nice 3, France

[4] Chem Inst Nat Subst, Gif Res Ctr, F-91198 Gif Sur Yvette, France

[5] Aix Marseille Univ, Mediterranean Inst Biodivers & Marine & Continent, Stn Marine Endoume, CNRS,UMR 7263, F-13007 Marseille, France

来源：

MARINE DRUGS | 2013年 / 11卷 / 07期

关键词：

marine natural products; highly oxygenated polyacetylenes; marine sponges; Porifera; Haplosclerida; XESTOSPONGIA SP;

D O I：

10.3390/md11072282

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new C-47 polyoxygenated acetylenic acid, nepheliosyne B (2), along with the previously described nepheliosyne A (1), have been isolated from the New Caledonian marine sponge Niphates sp. Their structures have been elucidated on the basis of extensive spectroscopic analyses. These metabolites exhibited a moderate cytotoxicity against K562, U266, SKM1, and Kasumi cancer cell lines.

引用

页码：2282 / 2292

页数：11

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