In Vitro Activity of Bedaquiline and Delamanid against Nontuberculous Mycobacteria, Including Macrolide-Resistant Clinical Isolates

被引：45
|
作者：
Kim, Dae Hun [1 ]
Jhun, Byung Woo [1 ]
Moon, Seong Mi [1 ]
Kim, Su-Young [1 ]
Jeon, Kyeongman [1 ]
Kwon, O. Jung [1 ]
Huh, Hee Jae [2 ]
Lee, Nam Yong [2 ]
Shin, Sung Jae [3 ,4 ,5 ]
Daley, Charles L. [6 ,7 ]
Koh, Won-Jung [1 ]
机构：
[1] Sungkyunkwan Univ, Sch Med, Div Pulm & Crit Care Med, Dept Med,Samsung Med Ctr, Seoul, South Korea
[2] Sungkyunkwan Univ, Sch Med, Dept Lab Med & Genet, Samsung Med Ctr, Seoul, South Korea
[3] Yonsei Univ, Coll Med, Dept Microbiol, Seoul, South Korea
[4] Yonsei Univ, Coll Med, Inst Immunol & Immunol Dis, Seoul, South Korea
[5] Yonsei Univ, Coll Med, Brain Korea 21 PLUS Project Med Sci, Seoul, South Korea
[6] Natl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO USA
[7] Univ Colorado, Dept Med, Aurora, CO USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
Mycobacterium abscessus; Mycobacterium avium complex; Mycobacteriurn kansasii; bedaquiline; delamanid; nontuberculous mycobacteria; TREATMENT OUTCOMES; PULMONARY-DISEASE; DIAGNOSIS; EMERGENCE; MECHANISM; DRUG;
D O I：
10.1128/AAC.00665-19
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We evaluated the in vitro activities of the antimicrobial drugs bedaquiline and delamanid against the major pathogenic nontuberculous mycobacteria (NTM). Delamanid showed high MIC values for all NTM except Mycobacterium kansasii. However, bedaquiline showed low MIC values for the major pathogenic NTM, including Mycobacterium avium complex, Mycobacterium abscessus subsp. abscessus, M. abscessus subsp. massiliense, and M. kansasii. Bedaquiline also had low MIC values with macrolide-resistant NTM strains and warrants further investigation as a potential antibiotic for NTM treatment.
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页数：6
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