Kinetics of CD4 cells after discontinuation of antiretroviral therapy in patients with virological failure and a CD4 cell count greater than 500 cells/μl

被引：20

作者：

Mussini, C ^{[1
]}

Bugarini, R

Perno, CF

Antinori, A

Borghi, V

Bertoli, A

D'Arrigo, R

Bedini, A

Mongiardo, N

Cossarizza, A

Esposito, R

机构：

[1] Univ Modena, Clin Infect & Trop Dis, I-41100 Modena, Italy

[2] Azienda Policlin, I-41100 Modena, Italy

[3] Ist Super Sanita, I-00161 Rome, Italy

[4] IRCCS, Natl Inst Infect Dis L Spallanzani, Rome, Italy

[5] Univ Modena, Dept Biomed Sci, I-41100 Modena, Italy

来源：

AIDS | 2002年 / 16卷 / 11期

关键词：

D O I：

10.1097/00002030-200207260-00013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

After a median of 37 months on antiretroviral therapy, 16 patients were asked to discontinue treatment instead of changing it. After a median observation time of 10.5 months, most patients experienced a rapid and progressive decrease in their CD4 cell count, even without a high viral load rebound. This decline was unrelated to the CD4 cell count and HIV-RNA values at interruption, but was more profound in patients in whom the M184V mutation had disappeared after lamivudine discontinuation.

引用

页码：1551 / 1554

页数：4

共 50 条

[41] The impact of episodic CD4 cell count-guided antiretroviral therapy on quality of life
Burman, William J.
Grund, Birgit
Roedige, Mollie P.
Friedland, Gerald
Darhyshire, Janet
Wu, Albert W.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2008, 47 (02) : 185 - 193
[42] Immunologic Failure Despite Suppressive Antiretroviral Therapy Is Related to Activation and Turnover of Memory CD4 Cells
Lederman, Michael M.
Calabrese, Leonard
Funderburg, Nicholas T.
Clagett, Brian
Medvik, Kathy
Bonilla, Hector
Gripshover, Barbara
Salata, Robert A.
Taege, Alan
Lisgaris, Michelle
McComsey, Grace A.
Kirchner, Elizabeth
Baum, Jane
Shive, Carey
Asaad, Robert
Kalayjian, Robert C.
Sieg, Scott F.
Rodriguez, Benigno
JOURNAL OF INFECTIOUS DISEASES, 2011, 204 (08): : 1217 - 1226
[43] Increase in CD4 cell counts between 2 and 3.5 years after initiation of antiretroviral therapy and determinants of CD4 progression in India
Rajasekaran, S.
Jeyaseelan, L.
Raja, K.
Vijila, S.
Krithigaipriya, K. A.
Kuralmozhi, R.
JOURNAL OF POSTGRADUATE MEDICINE, 2009, 55 (04) : 261 - 266
[44] Pneumocystis jirovecii Pneumonia in a HIV-Infected Patient with a CD4 Count Greater Than 400 Cells/μL and Atovaquone Prophylaxis
Nevez, Gilles
Hoffmann, Claire
Le Gal, Solene
CASE REPORTS IN INFECTIOUS DISEASES, 2023, 2023
[45] Pneumocystis jirovecii Pneumonia in a HIV-Infected Patient with a CD4 Count Greater Than 400 Cells/μL and Atovaquone Prophylaxis
Sullivan, Abigayle
Lanham, Theresa
Krol, Ronald
Zachariah, Shilla
CASE REPORTS IN INFECTIOUS DISEASES, 2020, 2020
[46] Changes in the slope of the CD4 cell count increase after initiation of potent antiretroviral treatment
Bosch, Ronald J.
Wang, Rui
Vaida, Florin
Lederman, Michael M.
Albrecht, Mary A.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2006, 43 (04) : 433 - 435
[47] Benefits of antiretroviral therapy for asymptomatic HIV-infected patients, regardless of CD4 count
Le Moal, G.
MEDECINE ET MALADIES INFECTIEUSES, 2016, 46 (03): : 174 - 175
[48] Drug-resistant mutants of HIV-1 in patients exhibiting increasing CD4 cell count despite virological failure of highly active antiretroviral therapy
Antinori, A
Liuzzi, G
Cingolani, A
Bertoli, A
Di Giambenedetto, S
Trotta, MP
Rizzo, MG
Girardi, E
De Luca, A
Perno, CF
AIDS, 2001, 15 (17) : 2325 - 2327
[49] CD4 cell count and CD4/CD8 ratio increase during rituximab maintenance in granulomatosis with polyangiitis patients
Besada, Emilio
Nossent, Johannes C.
PEERJ, 2016, 4
[50] Sustained CD4 responses after virological failure of protease inhibitor-containing therapy
Deeks, SG
Grant, RM
ANTIVIRAL THERAPY, 1999, 4 : 7 - 11

← 1 2 3 4 5 →