Kinetics of CD4 cells after discontinuation of antiretroviral therapy in patients with virological failure and a CD4 cell count greater than 500 cells/μl

被引：20

作者：

Mussini, C ^{[1
]}

Bugarini, R

Perno, CF

Antinori, A

Borghi, V

Bertoli, A

D'Arrigo, R

Bedini, A

Mongiardo, N

Cossarizza, A

Esposito, R

机构：

[1] Univ Modena, Clin Infect & Trop Dis, I-41100 Modena, Italy

[2] Azienda Policlin, I-41100 Modena, Italy

[3] Ist Super Sanita, I-00161 Rome, Italy

[4] IRCCS, Natl Inst Infect Dis L Spallanzani, Rome, Italy

[5] Univ Modena, Dept Biomed Sci, I-41100 Modena, Italy

来源：

AIDS | 2002年 / 16卷 / 11期

关键词：

D O I：

10.1097/00002030-200207260-00013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

After a median of 37 months on antiretroviral therapy, 16 patients were asked to discontinue treatment instead of changing it. After a median observation time of 10.5 months, most patients experienced a rapid and progressive decrease in their CD4 cell count, even without a high viral load rebound. This decline was unrelated to the CD4 cell count and HIV-RNA values at interruption, but was more profound in patients in whom the M184V mutation had disappeared after lamivudine discontinuation.

引用

页码：1551 / 1554

页数：4

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