Elevations in the Cholesterol Metabolite 27-Hydroxycholesterol Cause Insulin Resistance in Mice

被引:0
|
作者
Barrera, Jose A. [1 ]
Chambliss, Ken L. [1 ]
Tanigaki, Keiji [1 ]
Umetani, Michihisa [1 ]
Mineo, Chieko [1 ]
Shaul, Philip W. [1 ]
机构
[1] UT SW Med Ctr Dallas, Dallas, TX USA
关键词
Lipids; Insulin resistance; Estrogen; Adipose;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
15888
引用
收藏
页数:1
相关论文
共 50 条
  • [31] CHOLESTEROL AND 27-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLATION - EVIDENCE FOR 2 DIFFERENT ENZYMES
    MARTIN, KO
    BUDAI, K
    JAVITT, NB
    JOURNAL OF LIPID RESEARCH, 1993, 34 (04) : 581 - 588
  • [32] 7 alpha-hydroxylation of 27-hydroxycholesterol: Biologic role in the regulation of cholesterol synthesis
    Martin, KO
    Reiss, AB
    Lathe, R
    Javitt, NB
    JOURNAL OF LIPID RESEARCH, 1997, 38 (05) : 1053 - 1058
  • [33] The cholesterol/ 27-hydroxycholesterol axis is a novel therapeutic target in castrate resistant prostate cancer
    Alfaqih, Mahmoud A.
    Nelson, Erik R.
    Safi, Rachid
    Jasper, Jeff
    Chang, Ching-yi
    Freedland, Stephen J.
    McDonnell, Donald P.
    CANCER RESEARCH, 2014, 74 (19)
  • [34] Alterations of peripheral cholesterol metabolites, 24S-and 27-hydroxycholesterol in demented patients
    Kölsch, H
    Heun, R
    Jessen, F
    von Bergmann, K
    Maier, W
    Lütjohann, D
    NEUROBIOLOGY OF AGING, 2004, 25 : S351 - S351
  • [35] 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells
    Fu, X
    Menke, JG
    Chen, YL
    Zhou, GC
    MacNaul, KL
    Wright, SD
    Sparrow, CP
    Lund, EG
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (42) : 38378 - 38387
  • [36] Plasma 27-hydroxycholesterol/cholesterol ratio is increased in low high density lipoprotein-cholesterol healthy subjects
    Nunes, Valeria S.
    Leanca, Camila C.
    Panzoldo, Natalia B.
    Parra, Eliane
    Zago, Vanessa
    Cazita, Patricia M.
    Nakandakare, Edna R.
    de Faria, Eliana C.
    Quintao, Eder C. R.
    CLINICAL BIOCHEMISTRY, 2013, 46 (15) : 1619 - 1621
  • [37] Serum concentration of 27-hydroxycholesterol predicts the effects of high-cholesterol diet on plasma LDL cholesterol level
    Hirayama, Takeshi
    Mizokami, Yuji
    Honda, Akira
    Homma, Yasuhiko
    Ikegami, Tadashi
    Saito, Yoshifumi
    Miyazaki, Teruo
    Matsuzaki, Yasushi
    HEPATOLOGY RESEARCH, 2009, 39 (02) : 149 - 156
  • [38] 27-HYDROXYCHOLESTEROL CONTRIBUTES TO DISRUPTIVE EFFECTS ON LEARNING AND MEMORY BY MODULATING CHOLESTEROL METABOLISM IN THE RAT BRAIN
    Zhang, D. -D.
    Yu, H. -L.
    Ma, W. -W.
    Liu, Q. -R.
    Han, J.
    Wang, H.
    Xiao, R.
    NEUROSCIENCE, 2015, 300 : 163 - 173
  • [39] Plasma 27-hydroxycholesterol/cholesterol Ratio is Increased in Low High Density Lipoprotein-Cholesterol Healthy Subjects
    Nunes, Valeria S.
    LeanCa, Camila C.
    Panzoldo, Natalia B.
    Parra, Eliane
    Zago, Vanessa
    Cazita, Patricia M.
    Nakandakare, Edna R.
    de Faria, Eliana C.
    Quintao, Eder C.
    CIRCULATION, 2012, 126 (21)
  • [40] The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells
    Raza, Shaneabbas
    Ohm, Joyce E.
    Dhasarathy, Archana
    Schommer, Jared
    Roche, Conor
    Hammer, Kimberly D. P.
    Ghribi, Othman
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2015, 410 (1-2) : 187 - 195