Making structural sense of nonsense-mediated decay

被引：3

作者：

Lykke-Andersen, J ^{[1
]}

机构：

[1] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2004年 / 11卷 / 04期

关键词：

D O I：

10.1038/nsmb0404-305

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new study reports the hUpf2-hUpf3b interaction domain structure and provides the first structural insight into the core of the nonsense-mediated decay pathway. Surprisingly, the RNA-recognition motif of hUpf3b, a domain typically involved in RNA binding, constitutes instead an interaction surface for hUpf2.

引用

页码：305 / 306

页数：3

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