Green Access to Multi-Component Synthesis of Spiropyranopyrazoles

被引：15
|
作者：
Pore, D. M. [1 ]
Hegade, P. G. [1 ]
Gaikwad, D. S. [1 ]
Patil, P. B. [1 ]
Patil, J. D. [1 ]
机构：
[1] Shivaji Univ, Dept Chem, Kolhapur 416004, Maharashtra, India
来源：
LETTERS IN ORGANIC CHEMISTRY | 2014年 / 11卷 / 02期
关键词：
Spiroheterocycles; catalyst-free; pyranopyrazole; environmentally-friendly; water; DIELS-ALDER-REACTIONS; ORGANIC-REACTIONS; ONE-POT; EFFICIENT; MALONONITRILE; ACCELERATION; DERIVATIVES; WATER;
D O I：
10.2174/15701786113106660069
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A catalyst-free multi-component synthesis of spiro[indoline-3,4'-pyrano[2,3-c]pyrazoles] is reported from in situ formed pyrazolone by exothermic reaction of ethyl acetoacetate with hydrazine hydrate, isatin and malononitrile in water at room temperature. A suggested mechanistic approach was supported by semi-empirical calculations. The transformation is carried out in water alone and thus achieved the highest level of green chemistry. Simple reaction conditions, easy work-up procedure and isolation of products are the auxiliary advantages of present protocol.
引用
收藏
页码：131 / 135
页数：5
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