Curcuminoids in Multi-Component Synthesis

被引：9
|
作者：
Ajavakom, Vachiraporn [1 ,2 ]
Yutthaseri, Thatsawan [1 ,2 ]
Chantanatrakul, Rachata [1 ,2 ]
Suksamrarn, Apichart [1 ,2 ]
Ajavakom, Anawat [3 ]
机构：
[1] Ramkhamhang Univ, Fac Sci, Dept Chem, Bangkok 10240, Thailand
[2] Ramkhamhang Univ, Fac Sci, Ctr Excellence Innovat Chem, Bangkok 10240, Thailand
[3] Chulalongkorn Univ, Fac Sci, Dept Chem, Nanotec CU Ctr Excellence Food & Agr, Bangkok 10330, Thailand
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 01期
关键词：
NATURAL-PRODUCTS; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ANALOGS; TETRAHYDROCURCUMIN; DERIVATIVES; 3,4-DIHYDROPYRIMIDINONES; CYTOTOXICITY; EFFICIENT; CHINESE;
D O I：
10.1002/jhet.3005
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The introduction of a 1,3-dicarbonyl unit in curcuminoid derivatives for multi-component reactions (MCRs) to furnish six-membered heterocyclic compounds has been reviewed. Attention has focused on the assembly of the three-component Biginelli reactions relating to curcumin or tetrahydrocurcumin (THC), aromatic aldehydes and urea as substrates. The hybrid molecules of two bioactive agents were designed and synthesized by using these MCRs concepts. The four-component modified Hantzsch condensation was the latest development of this synthetic route. The possible mechanism of the MCRs of both curcumin and THC were also summarized.
引用
收藏
页码：13 / 20
页数：8
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