Humanized double knock-in mouse models for evaluating in vivo efficacy of the combination therapy of immune-oncology drugs

被引:0
|
作者
Gan, Tian [1 ]
Jin, James [2 ]
Guo, Chaoshe [1 ]
Shen, Yuelei [1 ]
Guo, Yanan [1 ]
机构
[1] Beijing Biocytogen Co Ltd, Beijing, Peoples R China
[2] Biocytogen LLC, Worcester, MA USA
关键词
D O I
10.1158/1538-7445.AM2018-5688
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
5688
引用
收藏
页数:2
相关论文
共 27 条
  • [21] Developing double knock-in models of human immune checkpoint targets (dKI HuGEMM) for efficacy assessment of combinatorial therapeutic antibodies
    Zheng, Lei
    He, Daniel Xianfei
    Sun, Ruilin
    An, Annie Xiaoyu
    Fei, Jian
    Li, Henry Qixiang
    Ouyang, Davy Xuesong
    CANCER RESEARCH, 2019, 79 (13)
  • [22] A controlled drug release device facilitates the identification of favorable combinations of immune-oncology drugs with targeted or cytotoxic drugs in a patient-derived humanized mouse model of renal cancer
    Jonas, Oliver
    Oswald, Eva
    Lashuk, Kanstantsin
    Ahn, Sebastian
    Schueler, Julia
    CANCER RESEARCH, 2022, 82 (12)
  • [23] A HIGH-THROUGHPUT IN SITU SCREEN TO IDENTIFY SYNERGISTIC COMBINATIONS OF IMMUNE-ONCOLOGY DRUGS WITH TARGETED AND CYTOTOXIC AGENTS IN A PATIENT-DERIVED HUMANIZED MOUSE MODEL OF RENAL CANCER
    Jonas, Oliver
    Oswald, Eva
    Lashuk, Kanstantsin
    Ahn, Sebastian
    Schuler, Julia
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A585 - A585
  • [24] Humanized SIRPA and double humanized SIRPA/CD47 B-NDG mouse models are promising tools for anti-SIRPα antibody in vivo efficacy studies.
    Hu, Yuting
    Zhao, Lei
    Liu, Yujie
    Hui, Li
    Yu, Zhaoxue
    CANCER RESEARCH, 2021, 81 (13)
  • [25] The efficacy of second-line tyrosine kinase inhibitor for patients with metastatic non-clear cell renal cell carcinoma following first-line immune-oncology combination therapy
    Fujita, Kazutoshi
    Matsushita, Yuto
    Toyoda, Shingo
    Kojima, Takahiro
    Yamashita, Shimpei
    Taniguchi, Hisanori
    Monji, Keisuke
    Ishiyama, Ryo
    Tatarano, Shuichi
    Masui, Kimihiko
    Nakamura, Eijiro
    Kaneko, Tomoyuki
    Kitano, Goshi
    Motoshima, Takanobu
    Shiraishi, Satoru
    Kira, Satoru
    Murashima, Takaya
    Hara, Hiroaki
    Matsumura, Hideaki
    Nishiyama, Naotaka
    Miyake, Hideaki
    Kitamura, Hiroshi
    Uemura, Hirotsugu
    WORLD JOURNAL OF UROLOGY, 2024, 42 (01)
  • [26] TUSC2 immunogene therapy enhances efficacy of immunotherapy and targeted drugs in human non-small cell lung cancer (NSCLC) in humanized mouse models
    Meraz, Ismail M.
    Majidi, Mourad
    Feng, Meng
    Shao, RuPing
    Ha, Min Jin
    Shpall, Elizabeth J.
    Roth, Jack A.
    CANCER RESEARCH, 2020, 80 (16)
  • [27] Novel IL4/IL4RA double humanized mouse models for in vivo efficacy evaluation of human IL4 or IL4RA antibodies in asthma models
    Su, Y.
    Zhou, X.
    Guo, C.
    Guo, Y.
    Shen, Y.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 1814 - 1814