Etiology, cancer stem cells and potential diagnostic biomarkers for esophageal cancer

被引：68

作者：

Liu, Kuancan ^{[1
,2
,3
]}

Zhao, Tingting ^{[1
,2
,3
]}

Wang, Junkai ^{[4
]}

Chen, Yunyun ^{[1
,2
,3
]}

Zhang, Rui ^{[1
,2
]}

Lan, Xiaopeng ^{[1
,2
]}

Que, Jianwen ^{[5
,6
]}

机构：

[1] Joint Logist Team, Hosp 900, Inst Lab Med, Fuzhou 350025, Fujian, Peoples R China

[2] Dongfang Hosp, Fuzhou 350025, Fujian, Peoples R China

[3] Xiamen Univ, Sch Med, Xiamen 361102, Fujian, Peoples R China

[4] Xiamen Univ, Sch Life Sci, Xiamen 361102, Fujian, Peoples R China

[5] Columbia Univ, Dept Med, Div Digest & Liver Dis, New York, NY 10032 USA

[6] Columbia Univ, Dept Med, Ctr Human Dev, New York, NY 10032 USA

来源：

CANCER LETTERS | 2019年 / 458卷

基金：

中国国家自然科学基金; 美国国家卫生研究院; 国家高技术研究发展计划(863计划);

关键词：

Esophageal squamous cell carcinoma; Esophageal adenocarcinoma; Barrett's esophagus; Basal cells; Cancer initiation cells; LONG NONCODING RNA; BARRETTS-ESOPHAGUS; PROGNOSTIC BIOMARKER; EXPRESSION PROFILE; INITIATING CELLS; CLINICAL IMPACT; POOR-PROGNOSIS; ADENOCARCINOMA; CARCINOMA; SERUM;

D O I：

10.1016/j.canlet.2019.05.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Esophageal cancer (EC) has been a leading cause of cancer death worldwide in part due to late detection and lack of precision treatment. EC includes two major malignancies, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). Recent studies reveal that ESCC and EAC have distinct cell of origin and contain cancer stem cells (also known as tumor initiating cells) expressing different cell surface markers. These biomarkers have potentially important values for both early detection and finding effective therapy. In this review we summarize the updated findings for cell of origin and provide an overview of cancer cell biomarkers that have been tested for ESCC and EAC. In addition, we also discuss recent progress in the study of molecular mechanisms leading to these malignancies.

引用

页码：21 / 28

页数：8

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