Colorectal Cancer Biomarkers and the Potential Role of Cancer Stem Cells

被引：58
|
作者：
Langan, Russell C. [1 ]
Mullinax, John E. [2 ]
Raiji, Manish T. [1 ]
Upham, Trevor [1 ]
Summers, Thomas [3 ]
Stojadinovic, Alexander [4 ,5 ]
Avital, Itzhak [6 ]
机构：
[1] Georgetown Univ Hosp, Washington, DC 20007 USA
[2] Univ S Florida, Med Ctr, Tampa, FL USA
[3] Walter Reed Natl Mil Med Ctr, Dept Anat Pathol, Bethesda, MD USA
[4] Walter Reed Natl Mil Med Ctr, Dept Surg, Div Surg Oncol, Bethesda, MD USA
[5] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA
[6] Bon Secours Canc Inst, Richmond, VA 23226 USA
来源：
JOURNAL OF CANCER | 2013年 / 4卷 / 03期
关键词：
Colorectal cancer; Cancer stem cells; Biomarkers; TUMOR MICROSATELLITE-INSTABILITY; SHORTENED PATIENT SURVIVAL; CONTRAST BARIUM ENEMA; FECAL OCCULT BLOOD; COLON-CANCER; 1ST-LINE TREATMENT; ADHESION MOLECULE; PROGNOSTIC VALUE; CT COLONOGRAPHY; MUTATION STATUS;
D O I：
10.7150/jca.5832
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Over 50% of patients with colorectal cancer (CRC) will progress and/or develop metastases. Biomarkers capable of predicting progression, risk stratification and therapeutic benefit are needed. Cancer stem cells are thought to be responsible for tumor initiation, dissemination and treatment failure. Therefore, we hypothesized that CRC stem cell markers (CRCSC) can identify a group of patients whom are at increased risk for recurrence or progression of disease. If proven correct, these CRCSC biomarkers may herald a paradigm shift in the treatment of this deadly disease. This manuscript reviews current CRC evidence based screening modalities, patient stratification, and summarizes the current state of biomarkers and discusses the novel concept of putative CRCSC's as prognostic biomarkers.
引用
收藏
页码：241 / 250
页数：10
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