Regio- and stereoselective synthesis of vicinal fluorohydrins

被引：54
|
作者：
Haufe, G [1 ]
机构：
[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany
来源：
JOURNAL OF FLUORINE CHEMISTRY | 2004年 / 125卷 / 06期
关键词：
condensation; enzyme-catalysis; epoxides; fluorohydrins; fluoroketones; hydrofluorination; reduction; resolution; ring opening; stereoselectivity; synthesis;
D O I：
10.1016/j.jfluchem.2004.01.023
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Vicinal fluorohydrins are useful building blocks as well as important targets for synthesis of bioactive compounds or new materials. This review gives an overview on regio- and stereoselective, particularly enantioselective, syntheses of such compounds by building block methods, reduction of alpha-fluoro carbonyl compounds and ring opening of epoxides with hydrofluorinating reagents. Resolution of racemic vicinal fluorohydrins using enzyme-catalyzed reactions will also be discussed in detail. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：875 / 894
页数：20
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