An updated advance of autoantibodies in autoimmune diseases

被引：121
|
作者：
Xiao, Ze Xiu [1 ]
Miller, Joseph S. [2 ]
Zheng, Song Guo [3 ,4 ]
机构：
[1] Sun Yat Sen Univ, Inst Clin Immunol, Affiliated Hosp 3, Guangzhou 510630, Peoples R China
[2] Ohio Univ, Heritage Coll Osteopath Med, Dublin 43016, OH, Ireland
[3] Ohio State Univ, Dept Internal Med, Coll Med, Columbus, OH 43210 USA
[4] Wexner Med Ctr, Columbus, OH 43210 USA
来源：
AUTOIMMUNITY REVIEWS | 2021年 / 20卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Autoantibody; Autoimmune disease; SLE; RA; MS; REGULATORY T-CELLS; COLLAGEN-INDUCED ARTHRITIS; TGF-BETA; RHEUMATOID-ARTHRITIS; SUPPRESS OSTEOCLASTOGENESIS; SODIUM-CHLORIDE; BONE EROSION; ANTIBODIES; LUPUS; DIAGNOSIS;
D O I：
10.1016/j.autrev.2020.102743
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Autoantibodies are abnormal antibodies which are generated by pathogenic B cells when targeting an individual's own tissue. Autoantibodies have been identified as a symbol of autoimmune disorders and are frequently considered a clinical marker of these disorders. Autoimmune diseases, including system lupus erythematosus and rheumatoid arthritis, consist of a series of disorders that share some similarities and differences. They are characterized by chronic, systemic, excessive immune activation and inflammation and involve in almost all body tissues. Autoimmune diseases occur more frequently in women than men due to hormonal impacts. In this review we systemically introduce and summarize the latest advances of various autoantibodies in multiple autoimmune diseases.
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页数：6
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