Recent advances in understanding the structure and function of general transcription factor TFIID

被引：73
|
作者：
Cler, Emilie [1 ]
Papai, Gabor [1 ]
Schultz, Patrick [1 ]
Davidson, Irwin [1 ]
机构：
[1] ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2009年 / 66卷 / 13期
关键词：
Drosophila; Yeast; Electron microscopy; Chromatin; Acetylation; Methylation; TATA-BINDING PROTEIN; HISTONE-FOLD; CORE PROMOTER; GENETIC-CHARACTERIZATION; CRYSTAL-STRUCTURE; YEAST; TAFS; SUBUNIT; COMPLEX; COACTIVATOR;
D O I：
10.1007/s00018-009-0009-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The general transcription factor TFIID is a macromolecular complex comprising the TATA-binding protein (TBP) and a set of 13-14 TBP associated factors (TAFs). This review discusses biochemical, genetic and electron microscopic data acquired over the past years that provide a model for the composition, organisation and assembly of TFIID. We also revisit ideas on how TFIID is recruited to the promoters of active and possibly repressed genes. Recent observations show that recognition of acetylated and methylated histone residues by structural domains in several TAFs plays an important role. Finally, we highlight several genetic studies suggesting that TFIID is required for initiation of transcription, but not for maintaining transcription once a promoter is in an active state.
引用
收藏
页码：2123 / 2134
页数：12
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