Efficacy of levetiracetam in pharmacoresistant continuous spikes and waves during slow sleep

被引：43

作者：

Capovilla, G ^{[1
]}

Beccaria, F ^{[1
]}

Cagdas, S ^{[1
]}

Montagnini, A ^{[1
]}

Segala, R ^{[1
]}

Paganelli, D ^{[1
]}

机构：

[1] C Poma Hosp, Dept Child Neuropsychiat, I-46100 Mantua, Italy

来源：

ACTA NEUROLOGICA SCANDINAVICA | 2004年 / 110卷 / 03期

关键词：

epilepsy; levetiracetam; continuous spikes and waves during slow sleep; electrical status epilepticus induced by sleep; treatment;

D O I：

10.1111/j.1600-0404.2004.00289.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective To evaluate the efficacy of levetiracetam (LEV) in continuous spikes and waves during slow sleep (CSWS). Despite first description dates back to 1971, no agreement exists about CSWS treatment. The condition is rare and controlled clinical trials are very difficult to perform, so the reports about efficacy of different drugs are anecdotal. Patientsand methods - We introduced LEV in three children affected by symptomatic focal epilepsy and pharmacoresistant CSWS and evaluated clinical, neuropsychological and electroencephalographic outcome. Results - Two cases responded completely, one case showed only a mild reduction of spikes and waves during slow sleep. Conclusion - Even if our report is anecdotal, LEV expands the spectrum of antiepileptic drugs that can be used for the treatment of CSWS. LEV efficacy should be confirmed in larger series.

引用

页码：144 / 147

页数：4

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