Deciphering the Role of Glutamate Signaling in Glioblastoma Multiforme: Current Therapeutic Modalities and Future Directions

被引：15

作者：

Mollazadeh, Hamid ^{[1
]}

Mohtashami, Elmira ^{[2
]}

Mousavi, Seyed H. ^{[3
]}

Soukhtanloo, Mohammad ^{[4
]}

Vahedi, Mohammad M. ^{[5
]}

Hosseini, Azar ^{[2
]}

Afshari, Amir R. ^{[1
]}

Sahebkar, Amirhossein ^{[6
,7
,8
]}

机构：

[1] North Khorasan Univ Med Sci, Fac Med, Dept Physiol & Pharmacol, Bojnurd, Iran

[2] Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, Iran

[3] Mashhad Univ Med Sci, Med Toxicol Res Ctr, Mashhad, Razavi Khorasan, Iran

[4] Mashhad Univ Med Sci, Fac Med, Dept Med Biochem, Mashhad, Razavi Khorasan, Iran

[5] Zahedan Univ Med Sci, Fac Med, Dept Pharmacol, Zahedan, Iran

[6] FDA, IRI, Halal Res Ctr, Tehran, Iran

[7] Mashhad Univ Med Sci, Biotechnol Res Ctr, Sch Med, Dept Med Biotechnol,Pharmaceut Technol Inst, POB 91779, Mashhad, Razavi Khorasan, Iran

[8] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran

来源：

CURRENT PHARMACEUTICAL DESIGN | 2020年 / 26卷 / 37期

关键词：

Glioblastoma multiforme; glutamate; antagonist; invasion; apoptosis; current therapeutic modalities; C6; GLIOMA-CELLS; AMPA RECEPTORS; METABOTROPIC GLUTAMATE-RECEPTOR-1; INHIBITS PROLIFERATION; PHARMACOLOGICAL BLOCKADE; MALIGNANT GLIOMA; HIGH EXPRESSION; NMDA RECEPTORS; STEM-CELLS; GROUP-II;

D O I：

10.2174/1381612826666200603132456

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

As the most popular intrinsic neoplasm throughout the brain, glioblastoma multiforme (GBM) is resistant to existing therapies. Due to its invasive nature, GBM shows a poor prognosis despite aggressive surgery and chemoradiation. Therefore, identifying and understanding the critical molecules of GBM can help develop new therapeutic strategies. Glutamatergic signaling dysfunction has been well documented in neurodegenerative diseases as well as in GBM. Inhibition of glutamate receptor activation or extracellular glutamate release by specific antagonists inhibits cell development, invasion, and migration and contributes to apoptosis and autophagy in GBM cells. This review outlines the current knowledge of glutamate signaling involvement and current therapeutic modalities for the treatment of GBM.

引用

页码：4777 / 4788

页数：12

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