Activation of the hTAS2R14 Human Bitter-Taste Receptor by (-)-Epigallocatechin Gal late and (-)-Epicatechin Gal late

被引：33

作者：

Yamazaki, Toyomi ^{[1
]}

Narukawa, Masataka ^{[2
]}

Mochizuki, Mineko ^{[1
]}

Misaka, Takumi ^{[2
]}

Watanabe, Tatsuo ^{[1
]}

机构：

[1] Univ Shizuoka, Grad Div Nutr & Environm Sci, Suruga Ku, Shizuoka 4228526, Japan

[2] Univ Tokyo, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2013年 / 77卷 / 09期

关键词：

green tea; catechin; bitter taste; bitter taste receptor; hTAS2R14; GREEN TEA CATECHINS; BLACK TEA; MICE; FAMILY; CELLS;

D O I：

10.1271/bbb.130329

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tea catechins have strong bitterness and influence the taste of tea. Among the 25 human bitter-taste receptors (TAS2Rs), we found that hTAS2R14 responded to catechins, in addition to hTAS2R39, a known catechin receptor. Although hTAS2R14 responded to (-)-epicatechin gallate and (-)-epigallocatechin gallate, it did not respond to (-)-epicatechin and (-)-epigallocatechin.

引用

页码：1981 / 1983

页数：3

共 50 条

[31] Identification of agonist interaction sites in the human bitter taste receptor hTAS2R10 through in silico model-guided mutagenesis
Born, Stephan
Behrens, Maik
Brockhoff, Anne
Levit, Anat
Niv, Masha Y.
Appendino, Giovanni
Meyerhof, Wolfgang
CHEMICAL SENSES, 2011, 36 (01) : E44 - E45
[32] Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium
Brockhoff, Anne
Behrens, Maik
Massarotti, Alberto
Appendino, Giovanni
Meyerhof, Wolfgang
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 55 (15) : 6236 - 6243
[33] Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14
Nowak, Stefanie
Di Pizio, Antonella
Levit, Anat
Niv, Masha Y.
Meyerhof, Wolfgang
Behrens, Maik
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2018, 1862 (10): : 2162 - 2173
[34] Functionally expressed bitter taste receptor TAS2R14 in human epidermal keratinocytes serves as a chemosensory receptor
Ho, Hilary Kung-Yu
Bigliardi, Paul Lorenz
Stelmashenko, Olga
Ramasamy, Srinivas
Postlethwaite, Michael
Bigliardi-Qi, Mei
EXPERIMENTAL DERMATOLOGY, 2021, 30 (02) : 216 - 225
[35] Variation in the bitter-taste receptor gene TAS2R38, and adiposity in a genetically isolated population in Southern Italy
Tepper, Beverly J.
Koelliker, Yvonne
Zhao, Liqiang
Ullrich, Natalia V.
Lanzara, Carmela
d'Adamo, Pio
Ferrara, Antonella
Ulivi, Sheila
Esposito, Laura
Gasparini, Paolo
OBESITY, 2008, 16 (10) : 2289 - 2295
[36] The human bitter taste receptor TAS2R7 facilitates the detection of bitter salts
Behrens, Maik
Redel, Ulrike
Blank, Kristina
Meyerhof, Wolfgang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 512 (04) : 877 - 881
[37] An Artemisia-derived natural product-based fluorescent probe for the bitter taste receptor hTAS2R38
Pollastro, Federica
Talmon, Maria
Gaeta, Simone
Rossi, Silvia
Lopatriello, Annalisa
Fresu, Luigia Grazia
FITOTERAPIA, 2018, 127 : 252 - 256
[38] Cholesterol modulates the signaling of chemosensory bitter taste receptor T2R14 in human airway cells
Shaik, Feroz Ahmed
Medapati, Manoj Reddy
Chelikani, Prashen
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2019, 316 (01) : L45 - L57
[39] N-geranyl cyclopropyl-carboxamide, an umami taste modulator interrupts salicin binding to hTAS2R16 bitter taste receptor
Rhyu, Mee-Ra
Kim, Yiseul
CHEMICAL SENSES, 2019, 44 (03) : E41 - E41
[40] The influence of bitter-taste receptor (TAS2R) expression in pharmacological response to Chloroquine in obese patients with COVID-19
Watanabe, Ligia Moriguchi
Pires, Izabella Ferreira
Noronha, Natalia Yumi
de Souza Pinhel, Marcela Augusta
Nonino, Carla Barbosa
CLINICS, 2020, 75

← 1 2 3 4 5 →