Guanacastane Diterpenoids from the Plant Endophytic Fungus Cercospora sp.

被引：29

作者：

Feng, Yu ^{[1
,5
]}

Ren, Fengxia ^{[2
]}

Niu, Shubin ^{[1
,5
]}

Wang, Lin ^{[1
,5
]}

Li, Li ^{[3
,4
]}

Liu, Xingzhong ^{[1
]}

Che, Yongsheng ^{[2
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100190, Peoples R China

[2] Beijing Inst Pharmacol & Toxicol, State Key Lab Antitox Drugs & Toxicol, Beijing 100850, Peoples R China

[3] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[4] Peking Union Med Coll, Beijing 100050, Peoples R China

[5] Univ Chinese Acad Sci, Beijing 100039, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 04期

基金：

北京市自然科学基金;

关键词：

ELECTRONIC CIRCULAR-DICHROISM; PESTALOTIOPSIS-MICROSPORA; NATURAL-PRODUCTS; TAXOL; INDUCTION;

D O I：

10.1021/np4009688

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Cercosporenes A-F (1-6, respectively), six new guanacastane diterpenes, including a homodimer (5) and a heterodimer (6), were isolated from the crude extract of the fungus Cercospora sp., endophytic to the medicinal plant Fallopia japonica. The structures of 1-6 were elucidated by nuclear magnetic resonance experiments, and 4 and 5 were further confirmed by X-ray crystallography. The absolute configuration of 1 and 3 was assigned by electronic circular dichroism calculations, whereas that of 6 was deduced by the application of the circular dichroism exciton chirality method. In addition to its cytotoxicity against a panel of five human tumor cell lines, HeLa, A549, MCF-7, HCT116, and T24, heterodimer 6 also induced autophagy in HCT116 cells.

引用

页码：873 / 881

页数：9

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