Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery

被引：34
|
作者：
Zhang, Yunlong [1 ,2 ,3 ]
Pelet, Jeisa M. [1 ,3 ]
Heller, Daniel A. [2 ,5 ]
Dong, Yizhou [3 ]
Chen, Delai [1 ]
Gu, Zhen [1 ,3 ]
Joseph, Brian J. [2 ,5 ]
Wallas, Jasmine [5 ]
Anderson, Daniel G. [1 ,2 ,3 ,4 ]
机构：
[1] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
[3] Childrens Hosp Boston, Dept Anesthesiol, Boston, MA 02115 USA
[4] MIT, Inst Med Engn & Sci, Cambridge, MA 02139 USA
[5] Mem Sloan Kettering Canc Ctr, Mol Pharmacol & Chem Program, New York, NY 10065 USA
来源：
ADVANCED MATERIALS | 2013年 / 25卷 / 33期
关键词：
siRNA; drug delivery; nanoparticle; gene knockdown; aminoglycoside; DOUBLE-STRANDED-RNA; CATIONIC LIPIDS; NANOPARTICLES; INTERFERENCE; EFFICIENT; POTENT; VECTORS;
D O I：
10.1002/adma.201301917
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Rationally designed siRNA delivery materials that are enabled by lipid-modified aminoglycosides are demonstrated. Leading materials identified are able to self-assemble with siRNA into well-defined nanoparticles and induce efficient gene knockdown both in vitro and in vivo. Histology studies and liver function tests reveal that no apparent toxicity is caused by these nanoparticles at doses over two orders of magnitude. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：4641 / 4645
页数：5
相关论文
共 50 条
  • [21] Enhanced Anti-Tumor Efficacy of Lipid-Modified Platinum Derivatives in Combination with Survivin Silencing siRNA in Resistant Non-Small Cell Lung Cancer
    George Mattheolabakis
    Dandan Ling
    Gulzar Ahmad
    Mansoor Amiji
    Pharmaceutical Research, 2016, 33 : 2943 - 2953
  • [22] ε-Caprolactone-Modified Polyethylenimine as Efficient Nanocarriers for siRNA Delivery in Vivo
    Xie, Lisi
    Tan, Yan
    Wang, Zhiyong
    Liu, Hong
    Zhang, Na
    Zou, Chao
    Liu, Xin
    Liu, Gang
    Lu, Jian
    Zheng, Hairong
    ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (43) : 29261 - 29269
  • [23] Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs)
    Benner, Nancy L.
    Near, Katherine E.
    Bachmann, Michael H.
    Contag, Christopher H.
    Waymouth, Robert M.
    Wender, Paul A.
    BIOMACROMOLECULES, 2018, 19 (07) : 2812 - 2824
  • [24] Surfactant-induced lysis of lipid-modified microgels
    Kraft, ML
    Moore, JS
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (51) : 12921 - 12922
  • [25] Lipid Bilayer Membrane Shape Remodeling by Lipid-Modified Ras Proteins
    Li, Zhenlong
    Janosi, Lorant
    Gorfe, Alemayehu Abebe
    BIOPHYSICAL JOURNAL, 2012, 102 (03) : 221A - 221A
  • [26] In vivo cellular delivery of siRNA
    Brink, Peter R.
    Robinson, Richard B.
    Rosen, Michael R.
    Cohen, Ira S.
    IDRUGS, 2010, 13 (06) : 383 - 387
  • [27] Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo
    Biscans, Annabelle
    Coles, Andrew
    Haraszti, Reka
    Echeverria, Dimas
    Hassler, Matthew
    Osborn, Maire
    Khvorova, Anastasia
    NUCLEIC ACIDS RESEARCH, 2019, 47 (03) : 1082 - 1096
  • [28] Lipid-modified proteins as biomarkers for cardiovascular disease: a review
    Ferri, N
    Paoletti, R
    Corsini, A
    BIOMARKERS, 2005, 10 (04) : 219 - 237
  • [29] Development of amino acid-modified biodegradable lipid nanoparticles for siRNA delivery
    Patel, Pratikkumar
    Fetse, John
    Lin, Chien -Yu
    Guo, Yuhan
    Hasan, Md Reaid
    Nakhjiri, Maryam
    Zhao, Zhen
    Jain, Akshay
    Cheng, Kun
    ACTA BIOMATERIALIA, 2022, 154 : 374 - 384
  • [30] Surfactant-induced lysis of lipid-modified microgels
    1600, American Chemical Society (123):
12345