A convenient synthesis of novel hydrazones and osazones of 2-hydrazino-3-phenyl-4(3H)-quinazolinone

A series of the hydrazones 3 was prepared in very good yields by the reaction of 2-hydrazino-3-phenyl-4(3H)-quinazolinone (1) with monosaccharides 2. Acetylation of the hydrazones using acetic anhydride in the presence of pyridine at room temperature gave the coresponding acetyl derivatives 4 in excellent yields. The reaction of three equivalents of 1 with one equivalent of monosaccharides 2 in acetic acid afforded the corresponding osazones 5 in poor yields. Acetylation of the osazones using acetic anhydride in the presence of pyridine at room temperature afforded the corresponding acetyl derivatives 6 in good yields.