IL-18, VCAM-1 and P-selectin as early biomarkers in normoalbuminuric Type 2 diabetes patients

被引：18

作者：

Al-Rubeaan, Khalid ^{[1
]}

Nawaz, Shaik S. ^{[2
]}

Youssef, Amira M. ^{[3
]}

Al Ghonaim, Mohammed ^{[4
]}

Siddiqui, Khalid ^{[2
]}

机构：

[1] King Saud Univ, Univ Diabet Ctr, Dept Med, Coll Med, Riyadh, Saudi Arabia

[2] King Saud Univ, Biochem Dept, Strateg Ctr Diabet Res, Riyadh, Saudi Arabia

[3] King Saud Univ, Univ Diabet Ctr, Biochem Dept, Registry Dept, Riyadh, Saudi Arabia

[4] King Saud Univ, King Khalid Universe Hosp, Coll Med, Riyadh, Saudi Arabia

来源：

BIOMARKERS IN MEDICINE | 2019年 / 13卷 / 06期

关键词：

diabetic kidney disease; diabetic retinopathy; IL-18; low eGFR; pathophysiological role; P-selectin; SAUDI-DKD; Type; 2; diabetes; VCAM-1; YKL-40; CHRONIC KIDNEY-DISEASE; INFLAMMATORY CYTOKINES; DYSFUNCTION; IMPAIRMENT; EXPRESSION; MOLECULES;

D O I：

10.2217/bmm-2018-0359

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: To investigate the pathophysiological role of different biomarkers in diabetic kidney disease (DKD) among normoalbuminuric patients with a low-estimated glomerular filtration rate (eGFR). Methods: In this cross-sectional study of 200 normoalbuminuric Type 2 diabetes patients, 28 patients (14%) had a low eGFR. Results: The IL-18, VCAM-1 and P-selectin levels were significantly higher at a low eGFR. On analyzing the area under the receiver operating characteristic curve, these biomarkers had significant diagnostic value and have important pathophysiological role in the progression of DKD. Conclusion: Among normoalbuminuric Type 2 diabetes patients, IL-18, VCAM-1 and P-selectinmay play a significant role in the prediction of early DKD. Further prospective studies need to be conducted to confirm this observation.

引用

页码：467 / 478

页数：12

共 50 条

[21] Autoperfused flow chamber reveals chemokine-mediated arrest of murine monocytes on a P-selectin/VCAM-1 substrate
Chesnutt, BC
Smith, ML
Huo, YQ
Ley, K
FASEB JOURNAL, 2004, 18 (04): : A655 - A656
[22] P-SELECTIN AND VCAM-1 ARE FOCALLY EXPRESSED IN HYPERCHOLESTEROLEMIC RABBITS PRIOR TO INTIMAL ACCUMULATION OF MACROPHAGES AND T-LYMPHOCYTES
SAKAI, A
KUME, N
OCHI, H
NISHI, E
MORIWAKI, H
TANOUE, K
KITA, T
CIRCULATION, 1995, 92 (08) : 2668 - 2668
[23] The effect of cilostazol(pletaal) on the plasma soluble E-selectin and VCAM-1 in type 2 diabetic patients
Kim, DM
Ihm, SH
Kim, H
Yoo, JY
Choi, M
Yoo, H
Park, S
DIABETES, 1999, 48 : A361 - A361
[24] Serum soluble ICAM-1, VCAM-1, L-selectin, and P-selectin levels as markers of infection and their relation to clinical severity in neonatal sepsis
Figueras-Aloy, Jose
Gomez-Lopez, Lilian
Rodriguez-Miguelez, Jose-Manuel
Salvia-Roiges, M. Dolors.
Jordan-Garcia, Iolanda
Ferrer-Codina, Inmaculada
Carbonell-Estrany, Xavier
Jimenez-Gonzalez, Rafael
AMERICAN JOURNAL OF PERINATOLOGY, 2007, 24 (06) : 331 - 338
[25] 丹参素对CD11b、P-selectin、ICAM-1、VCAM-1、E-selectin表达的影响
姜开余
顾振纶
阮长耿
中国药理学通报, 2000, (06) : 682 - 685
[26] Circulating IL-18 and the risk of type 2 diabetes in women
M. F. Hivert
Q. Sun
P. Shrader
C. S. Mantzoros
J. B. Meigs
F. B. Hu
Diabetologia, 2009, 52 : 2101 - 2108
[27] Circulating IL-18 and the risk of type 2 diabetes in women
Hivert, M. F.
Sun, Q.
Shrader, P.
Mantzoros, C. S.
Meigs, J. B.
Hu, F. B.
DIABETOLOGIA, 2009, 52 (10) : 2101 - 2108
[28] Recruitment of human leukocytes from whole blood onto immobilized VCAM-1, E-selectin, and P-selectin under shear conditions.
Reinhardt, PH
Kubes, P
FASEB JOURNAL, 1998, 12 (05): : A802 - A802
[29] Expression of VCAM-1, ICAM-1, E- and P-selectin and tumour-associated macrophages in renal cell carcinoma
Hemmerlein, B
Scherbening, J
Kugler, A
Radzun, HJ
HISTOPATHOLOGY, 2000, 37 (01) : 78 - 83
[30] Endothelial P-selectin and VCAM-1 each can function as primary adhesive mechanisms for T cells under conditions of flow
Konstantopoulos, K
Kukreti, S
Smith, CW
McIntire, LV
JOURNAL OF LEUKOCYTE BIOLOGY, 1997, 61 (02) : 179 - 187

← 1 2 3 4 5 →