Bidirectional control of spike timing by GABAA receptor-mediated inhibition during theta oscillation in CA1 pyramidal neurons

被引:11
|
作者
Kwag, Jeehyun [1 ]
Paulsen, Ole [1 ]
机构
[1] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3PT, England
基金
英国生物技术与生命科学研究理事会;
关键词
CA1 pyramidal neuron; gamma-aminobutyric acid-A receptor; hippocampus; inhibition; rat; spike timing; theta oscillation; TERM SYNAPTIC PLASTICITY; NETWORK OSCILLATIONS; PHASE PRECESSION; DENDRITIC I(H); CELL-TYPE; INTERNEURONS; HIPPOCAMPUS;
D O I
10.1097/WNR.0b013e32832f5cc7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Precisely controlled spike times relative to theta-frequency network oscillations play an important role in hippocampal memory processing. Here we study how inhibitory synaptic input during theta oscillation contributes to the control of spike timing. Using whole-cell patch-clamp recordings from CA1 pyramidal cells in vitro with dynamic clamp to simulate theta-frequency oscillation (5 Hz), we show that gamma-aminobutyric acid-A (GABA(A)) receptor-mediated inhibitory postsynaptic potentials (IPSPs) can not only delay but also advance the postsynaptic spike depending on the timing of the inhibition relative to the oscillation. Spike time advancement with IPSP was abolished by the h-channel blocker ZD7288 (10 mu M), suggesting that IPSPs can interact with intrinsic membrane conductances to yield bidirectional control of spike timing. NeuroReport 20:1209-1213 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码:1209 / 1213
页数:5
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