RGH-188, an atypical antipsychotic with dopamine D3/D2 antagonist/partial agonist properties:: In vitro characterisation

被引：0
|
作者：
Kiss, B. [1 ]
Laszlovszky, I. [1 ]
Horvath, A. [1 ]
Schmidt, E. [1 ]
Bugovics, Gy. [1 ]
Orosz, Sz. [1 ]
Hornok, K. [1 ]
Gyertyan, I. [1 ]
Agai-Csongor, E. [1 ]
Domany, Gy. [1 ]
Tihanyi, K. [1 ]
Szombathelyi, Zs. [1 ]
机构：
[1] G Richter Ltd, Budapest, Hungary
来源：
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 2006年 / 9卷
关键词：
D-3 RECEPTOR ANTAGONIST;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
引用
收藏
页码：S221 / S222
页数：2
相关论文
共 50 条
  • [21] Aripiprazole: a partial dopamine D2 receptor agonist antipsychotic
    Keck, PE
    McElroy, SL
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2003, 12 (04) : 655 - 662
  • [22] Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography
    Nicholas Seneca
    Sjoerd J. Finnema
    István Laszlovszky
    Béla Kiss
    Attila Horváth
    Gabriella Pásztor
    Margó Kapás
    István Gyertyán
    Sándor Farkas
    Robert B. Innis
    Christer Halldin
    Balázs Gulyás
    Psychopharmacology, 2011, 218 : 579 - 587
  • [23] Effects of the atypical antipsychotic and D3/D2 dopamine partial agonist cariprazine on effort-based choice behavior: implications for modeling avolition
    Ecevitoglu, Alev
    Edelstein, Gayle A.
    Presby, Rose E.
    Rotolo, Renee A.
    Yang, Jen-Hau
    Quiles, Taina
    Okifo, Kevin
    Conrad, Ryan T.
    Kovach, Ashley
    Correa, Merce
    Salamone, John D.
    PSYCHOPHARMACOLOGY, 2023, 240 (08) : 1747 - 1757
  • [24] Effects of the atypical antipsychotic and D3/D2 dopamine partial agonist cariprazine on effort-based choice behavior: implications for modeling avolition
    Alev Ecevitoglu
    Gayle A. Edelstein
    Rose E. Presby
    Renee A. Rotolo
    Jen-Hau Yang
    Taina Quiles
    Kevin Okifo
    Ryan T. Conrad
    Ashley Kovach
    Merce Correa
    John D. Salamone
    Psychopharmacology, 2023, 240 : 1747 - 1757
  • [25] Blonanserin, an Antipsychotic and Dopamine D2/D3 Receptor Antagonist, and Ameliorated Alcohol Dependence
    Takaki, Manabu
    Ujike, Hiroshi
    CLINICAL NEUROPHARMACOLOGY, 2013, 36 (02) : 68 - 69
  • [26] Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography
    Seneca, Nicholas
    Finnema, Sjoerd J.
    Laszlovszky, Istvan
    Kiss, Bela
    Horvath, Attila
    Pasztor, Gabriella
    Kapas, Margo
    Gyertyan, Istvan
    Farkas, Sandor
    Innis, Robert B.
    Halldin, Christer
    Gulyas, Balazs
    PSYCHOPHARMACOLOGY, 2011, 218 (03) : 579 - 587
  • [27] CHARACTERIZATION OF CARIPRAZINE (RGH-188) D3/D2 RECEPTOR OCCUPANCY IN HEALTHY VOLUNTEERS AND SCHIZOPHRENIC PATIENTS BY POSITRON EMISSION TOMOGRAPHY (PET)
    Laszlovszky, I.
    Gage, A.
    Kapas, M.
    Ghahramani, P.
    EUROPEAN PSYCHIATRY, 2010, 25
  • [28] The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure
    Holmes, Ian P.
    Blunt, Richard J.
    Lorthioir, Olivier E.
    Blowers, Stephen M.
    Gribble, Andy
    Payne, Andrew H.
    Stansfield, Ian G.
    Wood, Martyn
    Woollard, Patrick M.
    Reavill, Charlie
    Howes, Claire M.
    Micheli, Fabrizio
    Di Fabio, Romano
    Donati, Daniele
    Terreni, Silvia
    Hamprecht, Dieter
    Arista, Luca
    Worby, Angela
    Watson, Steve P.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (06) : 2013 - 2016
  • [29] Pharmacology of the atypical antipsychotic remoxipride, a dopamine D2 receptor antagonist
    Nadal, R
    CNS DRUG REVIEWS, 2001, 7 (03): : 265 - 282
  • [30] Cariprazine, a D3/D2 Dopamine Receptor Partial Agonist Antipsychotic, Displays Greater D3 Receptor Occupancy In Vivo Compared with Other Antipsychotics
    Kiss, Bela
    Horti, Ferenc
    Bobok, Amrita
    Adham, Nika
    BIOLOGICAL PSYCHIATRY, 2012, 71 (08) : 40S - 40S
12345