Tipping the balance toward longevity

被引：11
|
作者：
Antebi, A [1 ]
机构：
[1] Max Planck Inst Mol Genet, D-14195 Berlin, Germany
来源：
DEVELOPMENTAL CELL | 2004年 / 6卷 / 03期
关键词：
D O I：
10.1016/S1534-5807(04)00068-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Genetic experiments in C. elegans suggested that SIR2, an NAD-dependent protein deacetylase, acts through FOXO/DAF-16 transcription factor to prolong life. Recent studies show that mammalian SIR2 deacetylates FOXO, and may maximize survival by tempering cell death and increasing stress resistance.
引用
收藏
页码：315 / 316
页数：2
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