Tipping the Energy Balance toward Longevity

被引：9

作者：

Mair, William ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA

来源：

CELL METABOLISM | 2013年 / 17卷 / 01期

关键词：

LIFE-SPAN; DIETARY RESTRICTION; AMPK;

D O I：

10.1016/j.cmet.2012.11.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

AMPK is a cellular energy sensor conserved across eukaryotes that in C. elegans prolongs life span and mimics dietary restriction. Stenesen and colleagues (2012) activate AMPK both directly and indirectly by altering AMP biosynthesis to slow aging in Drosophila, highlighting AMPK as a conserved life span modulator that links energy sensing to longevity.

引用

页码：5 / 6

页数：2

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