Post-Translational Modification of ZEB Family Members in Cancer Progression

被引：18

作者：

Park, Mi Kyung ^{[1
,2
]}

Lee, Ho ^{[1
]}

Lee, Chang Hoon ^{[2
]}

机构：

[1] Natl Canc Ctr, Grad Sch Canc Sci & Policy, Dept Canc Biomed Sci, Goyang 10408, South Korea

[2] Dongguk Univ, Coll Pharm, Seoul 04620, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 23期

关键词：

zinc finger E-box binding homeobox (ZEB); post-translational modifications (PTM); cancer progression; EPITHELIAL-MESENCHYMAL TRANSITION; SMAD-INTERACTING PROTEIN-1; E-CADHERIN EXPRESSION; CELL CARCINOMA METASTASIS; PROMOTES TUMOR-METASTASIS; REGULATES E-CADHERIN; HOMEOBOX; ZEB1; NF-KAPPA-B; ZINC-FINGER; TGF-BETA;

D O I：

10.3390/ijms232315127

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Post-translational modification (PTM), the essential regulatory mechanisms of proteins, play essential roles in physiological and pathological processes. In addition, PTM functions in tumour development and progression. Zinc finger E-box binding homeobox (ZEB) family homeodomain transcription factors, such as ZEB1 and ZEB2, play a pivotal role in tumour progression and metastasis by induction epithelial-mesenchymal transition (EMT), with activation of stem cell traits, immune evasion and epigenetic reprogramming. However, the relationship between ZEB family members' post-translational modification (PTM) and tumourigenesis remains largely unknown. Therefore, we focussed on the PTM of ZEBs and potential therapeutic approaches in cancer progression. This review provides an overview of the diverse functions of ZEBs in cancer and the mechanisms and therapeutic implications that target ZEB family members' PTMs.

引用

页数：13

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