The cardiac myosin activator CK-1316719 increases myofibril ATPase activity and myocyte contractility in a rat model of heart failure

被引：0
|
作者：
Anderson, Robert L. [1 ]
Kawas, Raja F. [1 ]
Pokrovskii, Maria V. [1 ]
Godinez, Guillermo [1 ]
Lee, Kenneth L. [1 ]
Mak, John [1 ]
Morgan, Bradley P. [1 ]
Morgans, David J. [1 ]
Malik, Fady [1 ]
Sakowricz, Roman [1 ]
Elias, Kathleen A. [1 ]
机构：
[1] Cytokinetics, San Francisco, CA USA
来源：
CIRCULATION | 2006年 / 114卷 / 18期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：276 / 276
页数：1
相关论文
共 31 条
  • [21] Rationale and design for a phase II study evaluating the effect of the cardiac myosin activator, CK-1827452, on cardiac function, hemodynamics, and myocardial oxygen consumption in patients with heart failure
    Parker, J. D.
    Michaels, A. D.
    Kass, D. A.
    Wolff, A. A.
    Felker, G. M.
    Malik, F. I.
    JOURNAL OF CARDIAC FAILURE, 2008, 14 (06) : S79 - S79
  • [22] CHARACTERIZATION OF CARDIAC CONTRACTILITY AND MECHANICAL BEHAVIOR OF THE HEART IN A RAT MODEL OF CIRRHOTIC CARDIOMYOPATHY: THE ROLE OF BETA-MYOSIN HEAVY CHAIN OVEREXPRESSION
    Honar, Hooman
    Glenn, Tamara
    Zhang, Mei L.
    ter Keurs, Henk E.
    Lee, Samuel S.
    HEPATOLOGY, 2008, 48 (04) : 1060A - 1060A
  • [23] The Small-Molecule Fast Skeletal Troponin Activator, CK-2127107, Improves Exercise Tolerance in a Rat Model of Heart Failure
    Hwee, Darren T.
    Kennedy, Adam R.
    Hartman, James J.
    Ryans, Julie
    Durham, Nickie
    Malik, Fady I.
    Jasper, Jeffrey R.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2015, 353 (01): : 159 - 168
  • [24] Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure
    Ichihara, S
    Noda, A
    Nagata, K
    Obata, K
    Xu, JL
    Ichihara, G
    Oikawa, S
    Kawanishi, S
    Yamada, Y
    Yokota, M
    CARDIOVASCULAR RESEARCH, 2006, 69 (03) : 726 - 735
  • [25] REDUCED CARDIAC MYOFIBRILLAR MG-ATPASE ACTIVITY WITHOUT CHANGES IN MYOSIN ISOZYMES IN PATIENTS WITH END-STAGE HEART-FAILURE
    ALOUSI, AA
    GRANT, AM
    ETZLER, JR
    COFER, BR
    VANDERBELKAHN, J
    MELVIN, D
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 1990, 96 (01) : 79 - 88
  • [26] The rationale and design of the Acute Treatment with Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure (ATOMIC-AHF) study: a phase 2, cohort study of a novel cardiac myosin activator
    Teerlink, J. R.
    Felker, G. M.
    Mc Murray, J. J. V.
    Kim, J. B.
    Knusel, B.
    Lei, L.
    Malik, F. I.
    Wasserman, S. M.
    EUROPEAN JOURNAL OF HEART FAILURE, 2013, 12 : S308 - S309
  • [27] Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca2+-ATPase in a rat model of heart failure
    del Monte, F
    Williams, E
    Lebeche, D
    Schmidt, U
    Rosenzweig, A
    Gwathmey, JK
    Lewandowski, ED
    Hajjar, RJ
    CIRCULATION, 2001, 104 (12) : 1424 - 1429
  • [28] Augmentation of cardiac calcium-dependent nitric oxide synthase activity and nitric oxide production in a rat model of heart failure
    Khadour, FH
    Kao, RH
    Park, S
    Holycross, BJ
    Schulz, R
    CIRCULATION, 1996, 94 (08) : 3040 - 3040
  • [29] Olaparib, a Clinically Used Poly(adp-ribose) Polymerase Inhibitor, Protects Against Oxidant-Induced Cardiac Myocyte Death in vitro and Improves Cardiac Contractility During Early Phase After Heart Transplantation in an in vivo Rat Model
    Korkmaz-Icoz, Sevil
    Marcatti, Michela
    Li, Shiliang
    Ruppert, Mihaly
    Szczesny, Bartosz
    Lasitschka, Felix
    Loganathan, Sivakkanan
    Szabo, Csaba
    Szabo, Gabor
    CIRCULATION, 2017, 136
  • [30] Garlic (Allium sativum) exhibits a cardioprotective effect in experimental chronic renal failure rat model by reducing oxidative stress and controlling cardiac Na+/K+-ATPase activity and Ca2+ levels
    Asmaa M. S. Gomaa
    Alaa T. Abdelhafez
    Hazem A. Aamer
    Cell Stress and Chaperones, 2018, 23 : 913 - 920
1234