Identification of tyrosine hydroxylase as an autoantigen in autoimmune polyendocrine syndrome type I

被引:58
|
作者
Hedstrand, H [1 ]
Ekwall, O
Haavik, J
Landgren, E
Betterle, C
Perheentupa, J
Gustafsson, J
Husebye, E
Rorsman, F
Kämpe, O
机构
[1] Univ Hosp, Dept Med Sci, SE-75185 Uppsala, Sweden
[2] Univ Hosp, Dept Womens & Childrens Hlth, SE-75185 Uppsala, Sweden
[3] Univ Bergen, Dept Biochem & Mol Biol, Bergen, Norway
[4] Univ Padua, Inst Semeiot Med Clin Immunol & Allergy, Padua, Italy
[5] Univ Helsinki, Hosp Children & Adolescents, Helsinki, Finland
[6] Haukeland Univ Hosp, Div Endocrinol, Inst Med, N-5021 Bergen, Norway
关键词
alopecia areata; catecholamine biosynthesis; autoantibodies; tyrosine; 3-monooxygenase;
D O I
10.1006/bbrc.1999.1945
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Patients with the autosomal recessively inherited autoimmune polyendocrine syndrome type I (APS I) have autoantibodies directed against several endocrine and nonendocrine organs. In this study a new autoantigen related to this syndrome, tyrosine hydroxylase, was identified in sera from patients with alopecia areata through immunoscreening of a scalp cDNA library. Immunoreactivity against in vitro expressed tyrosine hydroxylase was found in 41 (44%) of the 94 APS I patients studied and this reactivity correlated with the presence of alopecia areata (P = 0.02). These findings further stress the importance of enzymes involved in neurotransmitter biosynthesis as important immune targets in APS I. (C) 2000 Academic Press.
引用
收藏
页码:456 / 461
页数:6
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