Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer

被引：24
|
作者：
Pawelek, John M. [1 ,2 ]
机构：
[1] Yale Univ, Sch Med, Dept Dermatol, New Haven, CT 06520 USA
[2] Yale Univ, Sch Med, Yale Canc Ctr, New Haven, CT 06520 USA
来源：
CHINESE JOURNAL OF CANCER | 2014年 / 33卷 / 03期
关键词：
Bone marrow-derived cell-cancer cell hybrids; metastasis; cell fusion; BETA-1,6-BRANCHED OLIGOSACCHARIDES; HYBRIDS; TUMOR; MELANIN;
D O I：
10.5732/cjc.013.10243
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This perspective article highlights the leukocyte-cancer cell hybrid theory as a mechanism for cancer metastasis. Beginning from the first proposal of the theory more than a century ago and continuing today with the first proof for this theory in a human cancer, the hybrid theory offers a unifying explanation for metastasis. In this scenario, leukocyte fusion with a cancer cell is a secondary disease superimposed upon the early tumor, giving birth to a new, malignant cell with a leukocyte-cancer cell hybrid epigenome.
引用
收藏
页码：133 / 139
页数：7
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