Doublecortin-like kinase 1 (DCLK1) correlates with Notch pathway signaling, controls metastatic characteristics in head and neck cancer

被引:0
|
作者
Broner, Esther Channah [1 ]
Subbannayya, Tejaswini [2 ]
Advani, Jayshree [2 ]
Zhavoronkov, Alex [3 ]
Artemov, Artem [3 ]
Ozerov, Ivan [3 ]
Sloma, Ido [4 ]
Gowda, Harsha [2 ]
Sidransky, David [1 ]
Izumchenko, Eugene [1 ]
Chatterjee, Aditi [2 ]
机构
[1] Johns Hopkins Univ, Baltimore, MD USA
[2] Inst Bioinformat, Bangalore, Karnataka, India
[3] Johns Hopkins Univ, Insilico Med Inc, ETC, Baltimore, MD USA
[4] Champ Oncol, Baltimore, MD USA
关键词
D O I
10.1158/1538-7445.AM2018-4512
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4512
引用
收藏
页数:1
相关论文
共 50 条
  • [41] DoubleCortin/Like Kinase 1 (DCLK1) expression characterized specific cancer stem cell subpopulations of human cholangiocarcinoma primary cell cultures where its inhibition exerts anti-neoplastic effects
    Di Matteo, Sabina
    Nevi, Lorenzo
    Cardinale, Vincenzo
    Zizzari, Ilaria Grazia
    Ambrosino, Valeria
    Biancaniello, Francesca
    Costantini, Daniele
    Safarikia, Samira
    De Peppo, Valerio
    De Rose, Agostino Maria
    Melandro, Fabio
    Bragazzi, Mariaconsiglia
    Giuliante, Felice
    Berloco, Pasquale B.
    Grazzi, Gianluca
    Carpino, Guido
    Gaudio, Eugenio
    Alvaro, Domenico
    JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E360 - E361
  • [42] Blocking of doublecortin-like kinase 1-regulated SARS-CoV-2 replication cycle restores cell signaling network
    Undi, Ram Babu
    Ahsan, Nagib
    Larabee, Jason L.
    Darlene-Reuter, Nicole
    Papin, James
    Dogra, Samrita
    Hannafon, Bethany N.
    Bronze, Michael S.
    Houchen, Courtney W.
    Huycke, Mark M.
    Ali, Naushad
    JOURNAL OF VIROLOGY, 2023, : e0119423
  • [43] Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1
    Nathaniel Weygant
    Dongfeng Qu
    William L Berry
    Randal May
    Parthasarathy Chandrakesan
    Daniel B Owen
    Sripathi M Sureban
    Naushad Ali
    Ralf Janknecht
    Courtney W Houchen
    Molecular Cancer, 13
  • [44] Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1
    Weygant, Nathaniel
    Qu, Dongfeng
    Berry, William L.
    May, Randal
    Chandrakesan, Parthasarathy
    Owen, Daniel B.
    Sureban, Sripathi M.
    Ali, Naushad
    Janknecht, Ralf
    Houchen, Courtney W.
    MOLECULAR CANCER, 2014, 13
  • [45] Doublecortin-like kinase 1 marks cancer stem-like cells and modulates drug-resistance, self-renewal, and tumorigenesis in renal cancer
    Ge, Yang
    Weygant, Nathaniel
    Qu, Dongfeng
    May, Randal
    Berry, William L.
    Chandrakesan, Parthasarathy
    Tomasek, James J.
    An, Guangyu
    Houchen, Courtney W.
    CANCER RESEARCH, 2016, 76
  • [46] miR-424-5p regulates cell proliferation, migration and invasion by targeting doublecortin-like kinase 1 in basal-like breast cancer
    Wang, Jianling
    Wang, Shibing
    Zhou, Jijun
    Qian, Qian
    BIOMEDICINE & PHARMACOTHERAPY, 2018, 102 : 147 - 152
  • [47] Overexpression of DCLK1 in pancreatic cancer activates KRAS/PI3K/MTOR pathway signaling and supports tumorigenesis, invasiveness, and sternness
    Qu, Dongfeng
    Weygant, Nathaniel
    May, Randal
    Berry, William
    Tomasek, James
    Chandrakesan, Parthasarathy
    Schlosser, Michael
    Houchen, Courtney
    CANCER RESEARCH, 2016, 76
  • [48] Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem-like Cells Marked by DCLK1 Kinase
    Weygant, Nathaniel
    Ge, Yang
    Qu, Dongfeng
    Kaddis, John S.
    Berry, William L.
    May, Randal
    Chandrakesan, Parthasarathy
    Bannerman-Menson, Edwin
    Vega, Kenneth J.
    Tomasek, James J.
    Bronze, Michael S.
    An, Guangyu
    Houchen, Courtney W.
    CANCER RESEARCH, 2016, 76 (14) : 4090 - 4099
  • [49] Targeting the PI3K/AKT/mTOR pathway offer a promising therapeutic strategy for cholangiocarcinoma patients with high doublecortin-like kinase 1 expression
    Liang, Ziwei
    Ge, Yang
    Li, Jianjian
    Bai, Yunting
    Xiao, Zeru
    Yan, Rui
    An, Guangyu
    Zhang, Donglei
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2024, 150 (07)
  • [50] Deregulation of NOTCH 1/NR4A2 signaling axis in head and neck cancer pathogenesis
    Chaudhary, Sanjib
    Pothuraju, Ramesh
    Sayed, Zafar
    Jones, Dwight T.
    Batra, Surinder K.
    Macha, Muzafar A.
    CLINICAL CANCER RESEARCH, 2020, 26 (12) : 45 - 45