A case for the use of receiver operating characteristic analysis of potential clinical efficacy biomarkers in advanced renal cell carcinoma

被引：19
|
作者：
English, Patricia A. [1 ]
Williams, J. Andrew [1 ]
Martini, Jean-Francois [1 ]
Motzer, Robert J. [2 ]
Valota, Olga [3 ]
Buller, Richard E. [1 ]
机构：
[1] Pfizer Oncol, San Diego, CA 92121 USA
[2] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
[3] Pfizer Oncol, I-20152 Milan, Italy
来源：
FUTURE ONCOLOGY | 2016年 / 12卷 / 02期
关键词：
biomarkers; renal cell carcinoma; ROC curves; serum soluble protein; sunitinib; 1ST-LINE SUNITINIB; THERAPY; CANCER;
D O I：
10.2217/fon.15.290
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: Assess patient-level utility of suggested pretreatment biomarkers of sunitinib in advanced renal cell carcinoma. Patients & methods: Kaplan-Meier analysis of data from a randomized, Phase II study (n = 292) suggested baseline predictive value for circulating soluble Ang-2 and MMP-2 and HIF-1 percentage of tumor expression. Using this dataset, the sensitivity, specificity and area under the curve (AUC) were calculated, using receiver operating characteristic (ROC) curves. Results: Based on a ROC (sensitivity vs 1 - specificity) threshold AUC value of >0.8, neither Ang-2 (0.67) nor MMP-2 (0.65), nor HIF-1 percentage of tumor expression (0.65), performed appropriately from a patient-selection standpoint. Conclusion: To properly assess potential biomarkers, sensitivity and specificity characteristics should be obtained by ROC analysis.
引用
收藏
页码：175 / 182
页数：8
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