Calcium Dobesilate Prevents Diabetic Kidney Disease by Decreasing Bim and Inhibiting Apoptosis of Renal Proximal Tubular Epithelial Cells

被引：21
|
作者：
Cai, Tian [1 ]
Wu, Xiao-yun [2 ,3 ]
Zhang, Xiao-qian [3 ]
Shang, Hong-xia [3 ]
Zhang, Zhong-wen [3 ]
Liao, Lin [3 ]
Dong, Jian-jun [4 ]
机构：
[1] Taian Hosp Tradit Chinese Med, Dept Med, Div Tradit Chinese Med, Tai An, Shandong, Peoples R China
[2] First Peoples Hosp Yunnan Prov, Dept Med, Div Geriatr, Kunming, Peoples R China
[3] Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Med, Div Endocrinol, Jinan 250014, Peoples R China
[4] Shandong Univ, Qilu Hosp, Dept Med, Div Endocrinol, Jinan 250014, Peoples R China
来源：
DNA AND CELL BIOLOGY | 2017年 / 36卷 / 04期
基金：
中国国家自然科学基金;
关键词：
apoptosis; Bim; proximal tubular epithelial cells; diabetic kidney disease; OXIDATIVE STRESS; NEPHROPATHY; ALBUMINURIA; RETINOPATHY; FILTRATION; DECLINE;
D O I：
10.1089/dna.2016.3276
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Apoptosis of renal proximal tubular epithelial cells (PTECs) plays a vital role in the pathogenesis and progression of diabetic kidney disease (DKD). Calcium dobesilate is a vascular protective compound used for treatment of diabetic retinopathy and chronic venous insufficiency. The aim of this study was to determine whether calcium dobesilate can protect PTECs from glucose- induced apoptosis and the potential mechanism of this effect. It is indicated that high glucose promoted abnormal apoptosis of HK2 cells, which was inhibited by treatment of calcium dobesilate, while Bim expression decreased in response to calcium dobesilate in highglucose- treated HK2 cells. These findings confirmed the therapeutic effects of calcium dobesilate on DKD and emphasized the importance of it as a potentially crucial drug in treatment of DKD.
引用
收藏
页码：249 / 255
页数：7
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