Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study

被引：12

作者：

Liu, Jiaqing ^{[1
,2
,3
,4
]}

Zhou, Huaqiang ^{[1
,2
,3
]}

Zhang, Yaxiong ^{[1
,2
,3
]}

Huang, Yan ^{[1
,2
,3
]}

Fang, Wenfeng ^{[1
,2
,3
]}

Yang, Yunpeng ^{[1
,2
,3
]}

Hong, Shaodong ^{[1
,2
,3
]}

Chen, Gang ^{[1
,2
,3
]}

Zhao, Shen ^{[1
,2
,3
]}

Chen, Xi ^{[1
,2
,3
]}

Zhang, Zhonghan ^{[1
,2
,3
]}

Shen, Jiayi ^{[4
]}

Xian, Wei ^{[4
]}

Zhan, Jianhua ^{[1
,2
,3
]}

Zhao, Yuanyuan ^{[1
,2
,3
]}

Hou, Xue ^{[1
,2
,3
]}

Ma, Yuxiang ^{[1
,2
,3
]}

Zhou, Ting ^{[1
,2
,3
]}

Zhao, Hongyun ^{[1
,2
,3
]}

Zhang, Li ^{[1
,2
,3
]}

机构：

[1] Sun Yat Sen Univ, Canc Ctr, Dept Med Oncol, Guangzhou, Guangdong, Peoples R China

[2] State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China

[3] Collaborat Innovat Ctr Canc Med, Guangzhou, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Zhongshan Sch Med, Guangzhou, Guangdong, Peoples R China

来源：

CANCER MEDICINE | 2019年 / 8卷 / 04期

基金：

国家重点研发计划;

关键词：

Causality; Docosapentaenoic acid; Lung cancer; Mendelian randomization; Polyunsaturated fatty acid; POLYUNSATURATED FATTY-ACIDS; SMOKING-CESSATION; N-3; OMEGA-3-FATTY-ACIDS; CHROMATOGRAPHY; PROLIFERATION; EPIDEMIOLOGY; MORTALITY; COHORT; MODEL;

D O I：

10.1002/cam4.2018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundObservational studies have shown that excessive dietary fat may be associated with lung carcinogenesis. However, findings from previous studies are inconsistent and it remains unclear whether docosapentaenoic acid (DPA), a kind of polyunsaturated fatty acid, is linked to the risk of lung cancer. The aim of this study is to investigate the causal effect of DPA on lung cancer with Mendelian randomization (MR) method. MethodsWith a two-sample MR approach, we analyzed the summary data from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE, 8866 individuals of European ancestry) Consortium and International Lung Cancer Consortium (ILCCO, 11348 lung cancer cases and 15861 controls; European ancestry) to assess the possible causal relationship of DPA on the risk of lung cancer. ResultsOur results indicated that genetically predicted higher DPA level has a positive association with lung cancer, where 1% higher DPA was associated with a 2.01-fold risk of lung cancer (odds ratio [OR]: 2.01, 95% CI=1.34-3.01; P=7.40x10(-4)). Additionally, lung cancer was not a causal factor for DPA. The results of MR-Egger regression analysis showed that there was no evidence for the presence of directional horizontal pleiotropy. ConclusionsGenetically elevated DPA is positively associated with risk of lung cancer, and more work is needed to investigate the potential mechanisms.

引用

页码：1817 / 1825

页数：9

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