Intracellular Staphylococcus aureus Control by Virulent Bacteriophages within MAC-T Bovine Mammary Epithelial Cells

被引：42

作者：

Zhang, Lili ^{[1
]}

Sun, Lichang ^{[1
]}

Wei, Ruicheng ^{[1
]}

Gao, Qiang ^{[1
]}

He, Tao ^{[1
]}

Xu, Cunfa ^{[2
]}

Liu, Xianjin ^{[1
]}

Wang, Ran ^{[1
]}

机构：

[1] Jiangsu Acad Agr Sci, Key Lab Control Technol & Stand Agroprod Safety &, Key Lab Food Qual & Safety Jiangsu Prov,Minist Ag, State Key Lab Breeding Base,Inst Food Qual & Safe, Nanjing, Jiangsu, Peoples R China

[2] Jiangsu Acad Agr Sci, Cent Lab, Nanjing, Jiangsu, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 02期

基金：

中国国家自然科学基金;

关键词：

MAC-T cells; Staphylococcus aureus; bacteriophages; PHAGE THERAPY; MYCOBACTERIOPHAGE; MACROPHAGES; MASTITIS; VIRUS; MICE;

D O I：

10.1128/AAC.01990-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bacteriophages (phages) are known to effectively kill extracellular multiplying bacteria. The present study demonstrated that phages penetrated bovine mammary epithelial cells and cleared intracellular Staphylococcus aureus in a timedependent manner. In particular, phage vB_SauM_JS25 reached the nucleus within 3 h postincubation. The phages had an endocytotic efficiency of 12%. This ability to kill intracellular host bacteria suggests the utility of phage-based therapies and may protect patients from recurrent infection and treatment failure.

引用

页数：4

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