Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat

被引：162
|
作者：
Homo-Delarche, Francoise
Calderari, Sophie
Irminger, Jean-Claude
Gangnerau, Marie-Noelle
Coulaud, Josiane
Rickenbach, Katharina
Dolz, Manuel
Halban, Philippe
Portha, Bernard
Serradas, Patricia
机构：
[1] Univ Paris 07, CNRS, UMR 7059, F-75005 Paris, France
[2] Univ Geneva, Med Ctr, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland
来源：
DIABETES | 2006年 / 55卷 / 06期
关键词：
D O I：
10.2337/db05-1526
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The molecular pathways leading to islet fibrosis in diabetes are unknown. Therefore, we studied gene expression in islets of 4-month-old Goto-Kakizaki (GK) and Wistar control rats. Of 71 genes found to be overexpressed in GK islets, 24% belong to extracellular matrix (ECM)/cell adhesion and 34% to inflammatory/immune response families. Based on gene data, we selected several antibodies to study fibrosis development during progression of hyperglycemia, by immunohistochemistry. One-month-old GK and Wistar islets appeared to be similar. Two-month-old GK islets were strongly heterogenous in terms of ECM accumulation compared with Wistar islets. GK islet vascularization, labeled by von Willebrand factor, was altered after 1 month of mild hyperglycemia. Numerous macrophages (major histocompatibility complex class II+ and CD68(+)) and granulocytes were found in/around GK islets. These data demonstrate that marked inflammatory reaction accompanies GK islet fibrosis and suggest that islet alterations in this nonobese model of type 2 diabetes develop in a way reminiscent of microangiopathy.
引用
收藏
页码：1625 / 1633
页数：9
相关论文
共 50 条
  • [31] Asiatic acid mitigates hyperglycemia and reduces islet fibrosis in Goto-Kakizaki rat,a spontaneous type 2 diabetic animal model
    WANG Xue
    LU Qian
    YU Dong-Sheng
    CHEN Yu-Peng
    SHANG Jing
    ZHANG Lu-Yong
    SUN Hong-Bin
    LIU Jun
    ChineseJournalofNaturalMedicines, 2015, 13 (07) : 529 - 534
  • [32] Type 2 diabetes -: a matter of failing β-cell neogenesis?: Clues from the GK rat model
    Movassat, J.
    Calderari, S.
    Fernandez, E.
    Martin, M. A.
    Escriva, F.
    Plachot, C.
    Gangnerau, M. N.
    Serradas, P.
    Alvarez, C.
    Portha, B.
    DIABETES OBESITY & METABOLISM, 2007, 9 : 187 - 195
  • [33] Asiatic acid mitigates hyperglycemia and reduces islet fibrosis in Goto-Kakizaki rat, a spontaneous type 2 diabetic animal model
    Wang Xue
    Lu Qian
    Yu Dong-Sheng
    Chen Yu-Peng
    Shang Jing
    Zhang Lu-Yong
    Sun Hong-Bin
    Liu Jun
    CHINESE JOURNAL OF NATURAL MEDICINES, 2015, 13 (07) : 529 - 534
  • [34] Ranolazine Attenuates Brain Inflammation in a Rat Model of Type 2 Diabetes
    Cassano, Velia
    Tallarico, Martina
    Armentaro, Giuseppe
    De Sarro, Caterina
    Iannone, Michelangelo
    Leo, Antonio
    Citraro, Rita
    Russo, Emilio
    De Sarro, Giovambattista
    Hribal, Marta Letizia
    Sciacqua, Angela
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (24)
  • [35] The α2-Adrenoceptor Antagonist Yohimbine Normalizes Increased Islet Blood Flow in GK Rats: A Model of Type 2 Diabetes
    Sandberg, M.
    Pettersson, U.
    Henriksnas, J.
    Jansson, L.
    HORMONE AND METABOLIC RESEARCH, 2013, 45 (03) : 252 - 254
  • [36] Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto-Kakizaki (GK) rat
    Giroix, M-H.
    Irminger, J-C.
    Lacraz, G.
    Noll, C.
    Calderari, S.
    Ehses, J. A.
    Coulaud, J.
    Cornut, M.
    Kassis, N.
    Schmidlin, F.
    Paul, J-L.
    Kergoat, M.
    Janel, N.
    Halban, P. A.
    Homo-Delarche, F.
    DIABETOLOGIA, 2011, 54 (09) : 2451 - 2462
  • [37] Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes
    Li, Xianquan
    Zhang, Lanjing
    Meshinchi, Sasha
    Dias-Leme, Claudia
    Raffin, Diane
    Johnson, Jeffery D.
    Treutelaar, Mary K.
    Burant, Charles F.
    DIABETES, 2006, 55 (11) : 2965 - 2973
  • [38] Anomalies of the actin cytoskeleton and malfunction of the beta cells in the Goto-Kakizaki rat (GK), a spontaneous model of type 2 diabetes (T2DM)
    Tourrel-Cuzin, C.
    Ilias, A.
    Auffret, J.
    Portha, B.
    Movassat, J.
    DIABETES & METABOLISM, 2009, 35 : A22 - A22
  • [39] Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes
    Zhou, Hong
    Li, Yong-jun
    Wang, Mian
    Zhang, Li-hui
    Guo, Bing-yan
    Zhao, Zhan-sheng
    Meng, Feng-ling
    Deng, Yong-gui
    Wang, Rui-ying
    ACTA PHARMACOLOGICA SINICA, 2011, 32 (08) : 999 - 1008
  • [40] Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes
    Hong Zhou
    Yong-jun Li
    Mian Wang
    Li-hui Zhang
    Bing-yan Guo
    Zhan-sheng Zhao
    Feng-ling Meng
    Yong-gui Deng
    Rui-ying Wang
    Acta Pharmacologica Sinica, 2011, 32 : 999 - 1008
12345