Limonoids from the Seeds of Chisocheton macrophyllus

被引：22

作者：

Nurlelasari ^{[1
]}

Katja, Dewa Gede ^{[1
]}

Harneti, Desi ^{[1
]}

Wardayo, Moelyono Moekti ^{[2
]}

Supratman, Unang ^{[1
]}

Awang, Khalijah ^{[3
]}

机构：

[1] Padjadjaran State Univ, Fac Math & Nat Sci, Dept Chem, Jatinangor 45262, Indonesia

[2] Padjadjaran State Univ, Fac Pharm, Jatinangor 45363, Indonesia

[3] Univ Malaya, Dept Chem, Fac Sci, Kuala Lumpur 59100, Malaysia

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2017年 / 53卷 / 01期

关键词：

dysobinol; limonoid; Chisocheton macrophyllus; P-388 murine leukemia cells; TRITERPENOIDS; PANICULATUS; SIAMENSIS; CERAMICUS; MELIACEAE; LEAVES; PLANTS; BARK;

D O I：

10.1007/s10600-017-1916-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new limonoid compound, dysobinol (1), along with three known limonoid compounds, 7 alpha-hydroxyneotricilenone (2), dysobinin (3), and nimonol (4), was isolated from the seeds of Chisocheton macrophyllus (Meliaceae). Their structures were established by spectroscopic techniques such as UV, IR, MS, 1D, and 2D NMR. Compounds 1-4 showed cytotoxic activity against P-388 murine leukemia cells with IC50 values of 49.7, 79.4, 19.5, and 64.5 mu g/mL, respectively.

引用

页码：83 / 87

页数：5

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