Antimicrobial Activity of New Cu(II) and MOO Heteroleptic Complexes Containing Bipyridine, Benzimidazole and Thiadiazole Derivatives

The synthesis and characterization of two new heteroleptic complexes of [M(II)L(tdz)(2)] type (where M(II) is Cu or Zn; L = 4,4'-dimethyl-2,2'-bipyridine or 2-hydroxymethyl-benzimidazole and tdz is 2,5-dimercapto-1,3,4-thiadiazole) have been described. The structures of the complexes were elucidated by elemental analysis, electronic absorption and infrared spectra, as well as molar electrical conductivities. All complexes are tetra-coordinated with N2S2 and NOS2 environment respectively in a square planar geometry and exhibit a strong ligand-to-ligand charge transfer band in 450-475 nm visible range. The biological (antibacterial and antifungal) activity of the synthesized complexes was compared with that of the heterocyclic ligands. The results indicated that the Cu(II) complexes have good biological activity similar or even higher than the clinical antibiotics.