Gold(III) complexes with hydroxyquinoline, aminoquinoline and quinoline ligands: Synthesis, cytotoxicity, DNA and protein binding studies

被引：28
|
作者：
Martin-Santos, Cecilia [1 ]
Michelucci, Elena [2 ]
Marzo, Tiziano [3 ]
Messori, Luigi [3 ]
Szumlas, Piotr [4 ]
Bednarski, Patrick J. [4 ]
Mas-Balleste, Ruben [1 ]
Navarro-Ranninger, Carmen [1 ]
Cabrera, Silvia [1 ]
Aleman, Jose [5 ]
机构：
[1] Univ Autonoma Madrid, Fac Ciencias, Dept Quim Inorgan Modulo 7, E-28049 Madrid, Spain
[2] Univ Florence, Mass Spectrometry Ctr CISM, I-50019 Florence, Italy
[3] Univ Florence, Dept Chem Ugo Schiff, Lab Met Med MET MED, I-50019 Florence, Italy
[4] Ernst Moritz Arndt Univ Greifswald, Inst Pharm, Pharmazeut Med Chem, D-17487 Greifswald, Germany
[5] Univ Autonoma Madrid, Fac Ciencias, Dept Quim Organ Modulo 1, E-28049 Madrid, Spain
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2015年 / 153卷
关键词：
Gold(III) complexes; Quinoline derivatives; Cytochrome c interaction; SULFONAMIDE PLATINUM COMPLEXES; ALZHEIMERS-DISEASE; SOLUTION CHEMISTRY; ANTITUMOR AGENTS; CLIOQUINOL; PROTEASOME; TARGETS; DERIVATIVES; DESIGN; COPPER;
D O I：
10.1016/j.jinorgbio.2015.09.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this article, we report on the synthesis and the chemical and biological characterization of novel gold(III) complexes based on hydroxyl- or amino-quinoline ligands that are evaluated as prospective anticancer agents. To gain further insight into their reactivity and possible mode of action, their interactions with model proteins and standard nucleic acid molecules were investigated. (C) 2015 Elsevier Inc All rights reserved.
引用
收藏
页码：339 / 345
页数：7
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