MitoCPR: Meticulous Monitoring of Mitochondrial Proteostasis

被引：6
|
作者：
Desai, Radha [1 ]
Campanella, Michelangelo [1 ,2 ]
机构：
[1] Univ London, Royal Vet Coll, Dept Comparat Biomed Sci, Royal Coll St, London NW1 0TU, England
[2] UCL, Consortium Mitochondrial Res CfMR, Gower St, London WC1E 6BT, England
来源：
MOLECULAR CELL | 2018年 / 71卷 / 01期
基金：
英国生物技术与生命科学研究理事会;
关键词：
PROTEIN IMPORT;
D O I：
10.1016/j.molcel.2018.06.027
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitochondrial protein import stress compromises functioning of the organelles, due to inadequate supply of inner mitochondrial proteins. Weidberg and Amon (2018) describe a new monitoring pathway in budding yeast, which restores mitochondrial function following the clearing of accumulated unfolded pre-transported mitochondrial proteins, by devising a molecular strategy of overexpressing bi-partite-containing mitochondrial proteins.
引用
收藏
页码：8 / 9
页数：2
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