Theoretical conformation of the closed and open states of the acetylcholine receptor channel

被引：17
|
作者：
Corry, B [1 ]
机构：
[1] Univ Western Australia, Dept Chem, Crawley, WA 6009, Australia
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2004年 / 1663卷 / 1-2期
关键词：
acetylcholine receptor; pore; ion channel; gating; brownian dynamic;
D O I：
10.1016/j.bbamem.2004.02.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We conduct a theoretical analysis to show the recently imaged structure of the acetylcholine receptor pore is in a non-conducting state. A hypothesised open state consistent with a lower resolution image is created and shown to have high conductance. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：2 / 5
页数：4
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