Effects of Nuclear Factor-E2-related factor 2/Heme Oxygenase 1 on splanchnic hemodynamics in experimental cirrhosis with portal hypertension

被引：6
|
作者：
Qin, Jun [1 ]
He, Yue [1 ]
Duan, Ming [1 ]
Luo, Meng [2 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Renji Hosp, Sch Med, Dept Gen Surg, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Gen Surg, Shanghai, Peoples R China
来源：
MICROVASCULAR RESEARCH | 2017年 / 111卷
基金：
中国国家自然科学基金;
关键词：
Portal hypertension; Heme Oxygenase 1; Contractile response; Splanchnic hemodynamics; Nuclear Factor-e2-related factor 2; OXIDATIVE STRESS; CARBON-MONOXIDE; HEME OXYGENASE; NITRIC-OXIDE; NRF2; PATHWAY; CARDIOVASCULAR-DISEASE; RATS; ACTIVATION; EXPRESSION; PROTECTS;
D O I：
10.1016/j.mvr.2016.12.009
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Objective: We explored the effects of Nuclear Factor-E2-related factor 2 (Nrf2) and Heme Oxygenase 1 (HO-1) on splanchnic hemodynamics in portal hypertensive rats. Methods: Experimental cirrhosis with portal hypertension was induced by intraperitoneal injection of carbon tetrachloride. The expression of proteins was examined by immunoblotting. Hemodynamic studies were performed by radioactive microspheres. The vascular perfusion system was used to measure the contractile response of mesentery arterioles in rats. Results: Nrf2 expression in the nucleus and HO-1 expression in cytoplasm was significantly enhanced in portal hypertensive rats. Portal pressure, as well as regional blood flow, increased significantly in portal hypertension and can be blocked by tin protoporphyrin IX. The expression of endogenous nitric oxide synthase and vascular endothelial growth factors increased significantly compared to normal rats, while HO-1 inhibition decreased the expression of these proteins significantly. The contractile response of mesenteric arteries decreased in portal hypertension, but can be partially recovered through tin protoporphyrin IX treatment. Conclusions: The expression of Nrf2/HO-1 increased in mesenteric arteries of portal hypertensive rats, which was related to oxidative stress. HO-1was involved in increased portal pressure and anomaly splanchnic hemodynamics in portal hypertensive rats. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：12 / 19
页数：8
相关论文
共 50 条
  • [21] Increased Heme Oxygenase-1 and Nuclear Factor Erythroid 2-Related Factor-2 in the Placenta Have a Cooperative Action on Preeclampsia
    Li, Jing
    Zhou, Jun
    Ye, Yuanhua
    Liu, Qunying
    Wang, Xiaojin
    Zhang, Ning
    Wang, Xietong
    GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 2016, 81 (06) : 543 - 551
  • [22] Methamphetamine (METH)-Initiated Cognitive Neurodevelopmental Deficits in Nuclear Factor-E2-Related Factor 2 (Nrf2)-Deficient Knockout Mice
    Ramkissoon, A.
    Wells, P. G.
    BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 2009, 85 (05) : 449 - 449
  • [23] Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor
    Kang, Kyoung Ah
    Lee, Kyoung Hwa
    Park, Jae Woo
    Lee, Nam Ho
    Na, Hye Kyung
    Surh, Young Joon
    You, Ho Jin
    Chung, Myung Hee
    Hyun, Jin Won
    FEBS LETTERS, 2007, 581 (10) : 2000 - 2008
  • [24] Heme oxygenase 1, nuclear factor E2-related factor 2, and nuclear factor κB are involved in hemin inhibition of type 2 cationic amino acid transporter expression and L-arginine transport in stimulated macrophages
    Tsai, Pei-Shan
    Chen, Chien-Chuan
    Tsai, Pei-Shan
    Yang, Lin-Cheng
    Huang, Wan-Yu
    Huang, Chun-Jen
    ANESTHESIOLOGY, 2006, 105 (06) : 1201 - 1210
  • [25] Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes
    Vargas, MR
    Pehar, M
    Cassina, P
    Martínez-Palma, L
    Thompson, JA
    Beckman, JS
    Barbeito, L
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (27) : 25571 - 25579
  • [26] Vitamin E Supplement Protects Against Gestational Diabetes Mellitus in Mice Through nuclear factor-erythroid factor 2-related factor 2/heme oxygenase-1 Signaling Pathway
    Lin, Bozhu
    Zhang, Xiaorong
    DIABETES METABOLIC SYNDROME AND OBESITY, 2023, 16 : 565 - 574
  • [27] In vivo and in vitro Approach to Anti-arthritic and Anti-inflammatory Effect of Crocetin by Alteration of Nuclear Factor-E2-Related Factor 2/hem Oxygenase (HO)-1 and NF-κB Expression
    Li, Yi
    Kakkar, Rajat
    Wang, Jian
    FRONTIERS IN PHARMACOLOGY, 2018, 9
  • [28] Sanguinarine Ameliorates Diabetic Nephropathy in Rats through Nuclear Factor-Kappa B and Nuclear-Factor Erythroid 2-Related Factor 2/Heme Oxygenase-1 Pathways
    Zhong, Jiao
    CURRENT TOPICS IN NUTRACEUTICAL RESEARCH, 2021, 19 (04) : 398 - 404
  • [29] Synergistic Interaction Between Heme Oxygenase (HO) and Nuclear-Factor E2-Related Factor-2 (Nrf2) against Oxidative Stress in Cardiovascular Related Diseases
    Ndisang, Joseph Fomusi
    CURRENT PHARMACEUTICAL DESIGN, 2017, 23 (10) : 1465 - 1470
  • [30] Hemin induced heme oxygenase-1 over expression involves nuclear factor-E2 related factor-2, nuclear factor-κB and extracellular regulated kinase:: An experimental study in a testicular torsion-detorsion rodent model
    Yang, Stone
    Shih, Hung-Jen
    Chow, Yung-Chiong
    Tsai, Pei-Shan
    Huang, Chun-Jen
    JOURNAL OF UROLOGY, 2008, 179 (06): : 2456 - 2463
12345