Neoadjuvant Systemic Treatment of Primary Angiosarcoma

被引:22
|
作者
Heinhuis, Kimberley M. [1 ]
Ijzerman, Nikki S. [1 ,2 ]
van der Graaf, Winette T. A. [1 ,3 ]
Kerst, Jan Martijn [1 ]
Schrage, Yvonne [4 ]
Beijnen, Jos H. [5 ,6 ]
Steeghs, Neeltje [1 ]
van Houdt, Winan J. [4 ]
机构
[1] Netherlands Canc Inst, Dept Med Oncol, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands
[2] Erasmus MC, Erasmus MC, Canc Inst, Dept Med Oncol, Doctor Molewaterpl 40, NL-3015 GD Rotterdam, Netherlands
[3] Radboudumc, Dept Med Oncol, Geert Grootepl 8, NL-6525 GA Nijmegen, Netherlands
[4] Netherlands Canc Inst, Dept Surg Oncol, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands
[5] Netherlands Canc Inst, Dept Pharm & Pharmacol, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands
[6] Univ Utrecht, Dept Pharmaceut Sci, Univ Weg 99, NL-3584 CG Utrecht, Netherlands
关键词
sarcomas; angiosarcoma; neoadjuvant treatment; neoadjuvant therapy; outcome; CUTANEOUS ANGIOSARCOMA; BREAST; CHEMOTHERAPY; OUTCOMES; SARCOMA; CANCER; GEMCITABINE; TISSUE; RISK; BRCA;
D O I
10.3390/cancers12082251
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Angiosarcoma is an extremely rare and aggressive malignancy. Standard of care of localized tumors includes surgery +/- radiation. Despite this multimodal treatment, >50% of the angiosarcoma patients develop local or distant recurrent disease. The role of neoadjuvant systemic therapy is still controversial and we therefore performed a systematic review of the literature to define the role of neoadjuvant systemic therapy based on available evidence. We focused on the effects of neoadjuvant systemic therapy on: 1. The success of surgical resection and 2. the long-term survival. All articles published before October 2019 on Ovid Medline, Ovid Embase, Cochrane library and Scopus were evaluated. Eighteen case reports and six retrospective cohort studies were included. There were no randomized controlled trials. This literature showed a beneficial role of neoadjuvant chemotherapy on downsizing of the tumor resulting in an improvement of the resection margins, especially in patients with cardiac or cutaneous angiosarcoma. However, no definitive conclusions on survival can be drawn based on the available literature lacking any prospective randomized studies in this setting. We advise that neoadjuvant chemotherapy should be considered, since this could lead to less mutilating resections and a higher rate of free resection margins. An international angiosarcoma registry could help to develop guidelines for this rare disease.
引用
收藏
页码:1 / 15
页数:15
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