Access to 5H-benzo[a]carbazol-6-ols and benzo[6,7]cyclohepta[1,2-b]indol-6-olsviarhodium-catalyzed C-H activation/carbenoid insertion/aldol-type cyclization

被引：22
|
作者：
Yuan, Yumeng [1 ]
Guo, Xiemin [1 ]
Zhang, Xiaofeng [1 ]
Li, Buhong [2 ]
Huang, Qiufeng [1 ]
机构：
[1] Fujian Normal Univ, Coll Chem & Mat Sci, Fujian Key Lab Polymer Mat, Fuzhou 350007, Fujian, Peoples R China
[2] Fujian Normal Univ, Fujian Key Lab Photon Technol, MOE Key Lab Optoelect Sci & Technol Med, Fuzhou 350007, Fujian, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2020年 / 7卷 / 20期
关键词：
ONE-POT SYNTHESIS; DIAZO-COMPOUNDS; OXIDATIVE ANNULATION; BOND ACTIVATION; DIRECTING GROUP; FUNCTIONALIZATION; INDOLES; OLEFINATION; CARBONYLATION; 2-ARYLINDOLES;
D O I：
10.1039/d0qo00820f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The rhodium-catalyzed mono-orthoC-H activation/carbenoid insertion/aldol-type cyclization of 3-aldehyde-2-phenyl-1H-indoles with diazo compounds has been developed. This method provides a novel approach to 5H-benzo[a]carbazol-6-ols and benzo[6,7]cyclohepta[1,2-b]indol-6-ols with a broad range of substrate scope in an air atmosphere. In addition, the synthetic potentialities of the developed approach are demonstrated by gram scale and versatile late-stage transformations.
引用
收藏
页码：3146 / 3159
页数：14
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