Determine the Effectiveness of 0.2% Topical Glyceryl Trinitrate in Preventing Postoperative wound Infection After Hemorrhoidectomy

Aim: To determine the effectiveness of 0.2% topical glyceryl trinitrate in prophylaxis of wound infection in patients undergoing milligan morgan hemorrhoidectomy. Study Design: Randomized controlled trial Place & Duration: Department of surgery Khairpur Medical College (KMC) Hospital, Khairpur Mirs, during the period from January 2019 to June 2019. Methods: One hundred and twenty four patients of both genders undergoing hemorrhoidectomy were enrolled in this study. Detailed demographics including age, sex, BMI and degree of hemorrhoids were recorded after taking written consent. All the patients were categorized into two equal groups. Group A with 62 patients received 0.2% of topical glyceryl trinitrate ointment and Group B received placebo. Postoperative wound infection was examined at 3rd week. Data was analyzed by SPSS 24.0. Results: In group A, 42 (67.74%) patients were males while 20 (32.26%) were females with mean age of 35.38 +/- 11.84 years. In group B 40 (64.52%) and 22 (35.48%) patients were males and females with mean age 36.02 +/- 10.96 years. No significant difference was observed regarding degree of hemorrhoids between both groups (p=>0.05). Patients received placebo (group B) had high rate of wound infection found in 29 (46.77%) patients as compared to patients who received 0.2% GTN 10 (11.29%), the difference was statistically significant (p=0.001). Conclusion: 0.2% glyceryl trinitrate ointment is effective for the prophylaxis of wound infection in patients undergoing milligan morgan hemorrhoidectomy.