Herpes simplex virus and Alzheimer's disease: a Mendelian randomization study

被引:33
|
作者
Kwok, Man Ki [1 ]
Schooling, Catherine Mary [1 ,2 ]
机构
[1] Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, 1-F,Patrick Manson Bldg North Wing,7 Sassoon Rd, Hong Kong, Peoples R China
[2] CUNY, Grad Sch Publ Hlth & Hlth Policy, New York, NY 10021 USA
关键词
Herpes simplex virus; Cognition; Alzheimer's disease; Mendelian randomization; INFECTIONS; DEMENTIA; RISK;
D O I
10.1016/j.neurobiolaging.2020.09.025
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
This study assessed if any herpes simplex virus (HSV) infection was a genetically valid target for late-onset Alzheimer's disease (AD) using 2-sample Mendelian randomization. We applied strong (p-value <5x10(-6)) and independent (r(2) < 0.05) genetic variants for any HSV infection (n = 450,581) to genome wide association studies of cognitive function (n = 300,486), and late-onset AD (n = 455,258) to obtain estimates. Genetically predicted log odds of any HSV infection was not associated with cognitive function (mean difference 0.0004 per any HSV infection, 95% confidence interval (CI) -0.001 to 0.001), or late-onset AD (odds ratio (OR) 0.999, 95% CI 0.998-1.001). Different genetic variant selections produced similar results. Any HSV infection does not appear to be a genetically valid target of intervention in late-onset AD, suggesting a rethink of the relevance of any HSV infection to late-onset AD. (C) 2020 Elsevier Inc. All rights reserved.
引用
收藏
页码:101.e11 / 101.e13
页数:3
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