A 90-day toxicity study of GmTMT transgenic maize in Sprague-Dawley rats

被引：10
|
作者：
Fang, Jin [1 ]
Feng, Yongquan [1 ]
Zhi, Yuan [1 ]
Zhang, Lan [2 ]
Yu, Zhou [1 ]
Jia, Xudong [1 ]
机构：
[1] Natl Ctr Food Safety Risk Assessment, Minist Hlth, Key Lab Food Safety Risk Assessment, 7 Panjiayuan Nanli, Beijing 100021, Peoples R China
[2] Chinese Acad Agr Sci, Biotechnol Res Inst, Natl Key Facil Crop Gene Resources & Genet Improv, Beijing 100081, Peoples R China
来源：
REGULATORY TOXICOLOGY AND PHARMACOLOGY | 2017年 / 85卷
关键词：
Transgenic maize; Toxicity; Feeding study; Rats; VITAMIN-E CONTENT; BT RICE TT51; REPRODUCTIVE-SYSTEM; GRAIN; PROGRESS; PLANTS; TOXICOLOGY; CORN;
D O I：
10.1016/j.yrtph.2017.01.004
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
GmTMT transgenic maize is a genetically modified maize plant that overexpresses the gamma-tocopherol methyltransferase (gamma-TMT) from Glycine max (Gm). The gamma-TMT gene was introduced into maize line Zhen58 to encode the GmTMT2a protein which can convert gamma-tocopherol into alpha-tocopherol. Over expression of GmTMT2a significantly increased the alpha-tocopherol content in transgenic maize. The present study was designed to investigate any potential effects of GmTMT maize grain in a 90-day subchronic rodent feeding study. Maize grains from GmTMT or Zhen58 were incorporated into rodent diets at low (12.5%), medium (25%) or high (50%) concentrations and administered to Sprague-Dawley rats (n = 10/sex/group) for 90 days. The negative control group of rats (n = 10/sex/group) were fed with common maize diets. Results from body weights, feed consumption, clinical chemistry, hematology, absolute and relative organ weights indicated no treatment-related side effects of GmTMT maize grain on rats in comparison with rats consuming diets containing Zhen58 maize grain. In addition, no treatment related changes were found in necropsy and histopathology examinations. Altogether, our data indicates that GmTMT transgenic maize is as safe and nutritious as its conventional non-transgenic maize. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：48 / 54
页数：7
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