p-Toluenesulfonohydrazide as Highly Efficient Initiator for Direct C-H Arylation of Unactivated Arenes

被引：43
|
作者：
Song, Qiao [1 ]
Zhang, Dongmei [2 ]
Zhu, Qihua [1 ]
Xu, Yungen [1 ,2 ]
机构：
[1] China Pharmaceut Univ, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 210009, Peoples R China
[2] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 20期
关键词：
ARYL HALIDES; ACTIVATION; HETEROCYCLES; BUTOXIDE; BENZENE; PROMOTE;
D O I：
10.1021/ol502370r
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
p-Toluenesulfonohydrazide (PTSH) was shown to promote the highly efficient direct arylation of unactivated arenes with aryl iodides, bromides, or chlorides in the presence of potassium tert-butoxide without the assistance of any transition metals. The reaction proceeds through base-promoted homolytic aromatic substitution (BHAS) involving aryl radicals and arylradical anions as intermediates.
引用
收藏
页码：5272 / 5274
页数：3
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