A Direct C-H Arylation of Unactivated Arenes Promoted by Mixed Potassium Alkoxides

被引：9
|
作者：
Wu, Yinuo [1 ,2 ,3 ]
Choy, Pui Ying [1 ,2 ]
Kwong, Fuk Yee [1 ,2 ]
机构：
[1] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, State Key Lab Chirosci, Kowloon, Hong Kong, Peoples R China
[2] Hong Kong Polytech Univ, Shenzhen Res Inst SZRI, Shenzhen, Peoples R China
[3] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510275, Guangdong, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 3卷 / 12期
关键词：
alkoxides; arenes; aryl iodides; arylation; metal-free; HOMOLYTIC AROMATIC-SUBSTITUTION; CATALYZED DIRECT ARYLATION; ARYL BOND FORMATION; COUPLING REACTIONS; RADICAL ARYLATION; VISIBLE-LIGHT; TERT-BUTOXIDE; HALIDES; BENZENE; ACTIVATION;
D O I：
10.1002/ajoc.201402181
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An intermolecular C-H arylation of unactivated arenes with aryl iodides is made viable through a transition-metal-free approach. This simple and efficient process obviates the common use of diamines or diols as the promoters. With the aid of only mixed potassium alkoxides, a number of unactivated arene C-H bonds can be directly arylated through a homolytic aromatic substitution (HAS) pathway.
引用
收藏
页码：1262 / 1265
页数：4
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